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Information Journal Paper

Title

GENE EXPRESSION AND PULMONARY TOXICITY OF CHITOSAN-GRAFT- POLYETHYLENIMINE AS AEROSOL GENE CARRIER

Pages

  281-286

Abstract

 Chitosan-graft-polyethylenimine (CHI-g-PEI) copolymer has been used for the improvement of low transfection efficiency of chitosan. The present study aims to test the PULMONARY TOXICITY and efficiency of CHI-g-PEI as an aerosol gene carrier. Mice were exposed to aerosol containing green-fluorescent protein (GFP) -polyethylenimine (PEI) or GFP-CHI-g-PEI complexes for 30 min during the development of our nose-only exposure chamber (NOEC) system. CHI-g-PEI-mediated AEROSOL DELIVERY demonstrated 15.65% enhancement of the fluorescence intensity. Compared to PEI, CHI-g-PEI showed no significant PULMONARY TOXICITY. In summary, using CHI-g-PEI is safe and shows high transfection in aerosol gene delivery to animals, and enhanced efficiency was achieved through our aerosol gene delivery system. Therefore, CHI-g-PEI and this system would be applicable to future study for aerosol gene therapy.

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    APA: Copy

    KWON, JUNG TAEK, JIANG, HU LIN, MINAI TEHRANI, ARASH, WOO, CHANG GYU, CHOI, MANSOO, CHO, CHONG SU, KIM, YEON SOO, & CHO, MYUNG HAING. (2013). GENE EXPRESSION AND PULMONARY TOXICITY OF CHITOSAN-GRAFT- POLYETHYLENIMINE AS AEROSOL GENE CARRIER. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(2), 281-286. SID. https://sid.ir/paper/288153/en

    Vancouver: Copy

    KWON JUNG TAEK, JIANG HU LIN, MINAI TEHRANI ARASH, WOO CHANG GYU, CHOI MANSOO, CHO CHONG SU, KIM YEON SOO, CHO MYUNG HAING. GENE EXPRESSION AND PULMONARY TOXICITY OF CHITOSAN-GRAFT- POLYETHYLENIMINE AS AEROSOL GENE CARRIER. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(2):281-286. Available from: https://sid.ir/paper/288153/en

    IEEE: Copy

    JUNG TAEK KWON, HU LIN JIANG, ARASH MINAI TEHRANI, CHANG GYU WOO, MANSOO CHOI, CHONG SU CHO, YEON SOO KIM, and MYUNG HAING CHO, “GENE EXPRESSION AND PULMONARY TOXICITY OF CHITOSAN-GRAFT- POLYETHYLENIMINE AS AEROSOL GENE CARRIER,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 2, pp. 281–286, 2013, [Online]. Available: https://sid.ir/paper/288153/en

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