INHIBITORY ACTIVITY OF AVICENNIA MARINA, A MEDICINAL PLANT IN PERSIAN FOLK MEDICINE, AGAINST HIV AND HSV

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NAMAZI RAHELE; ZABIHOLLAHI REZVAN; BEHBAHANI MANDANA; REZAEI ABBAS

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2013 | Volume:12 | Issue:2 Page(s): 435-443

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Title

INHIBITORY ACTIVITY OF AVICENNIA MARINA, A MEDICINAL PLANT IN PERSIAN FOLK MEDICINE, AGAINST HIV AND HSV

Author(s)

NAMAZI RAHELE | ZABIHOLLAHI REZVAN | BEHBAHANI MANDANA | REZAEI ABBAS | Issue Writer Certificate

Keywords

AVICENNIA MARINA

HERPES SIMPLEX VIRUS

HUMAN IMMUNODEFICIENCY VIRUS

ANTIVIRAL ACTIVITY

MEDICINAL PLANT

Abstract

AVICENNIA MARINA (Avicenniaceae) is a species of mangrove tree used for treatment of small pox lesions in Persian folk medicine. The ANTIVIRAL ACTIVITY of methanol, ethanol, water, chloroform and n-hexane extracts was evaluated against HIV-1 and HSV. Methanol extract had the highest ANTIVIRAL ACTIVITY and the most polar fraction of this extract (fraction D) inhibited HSV with TI and SI values of 57.1 and 133; however, it showed mild activity against HIV with SI value of 6.25 (fraction 3). The anti-HSV activity of active fraction was confirmed using FLASH-PCR. Phytochemical investigation revealed that fraction D encompasses flavonoids compounds. The time-of-addition study demonstrated that fraction D disturbs viral replication after penetrating to the cell. A. marina was endowed with fragments by which found to be able to inhibit replication of HSV after entry but did not show significant potency against HIV-1.This promotes further investigation in anti-HSV drug discovery.

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APA: Copy

NAMAZI, RAHELE, ZABIHOLLAHI, REZVAN, BEHBAHANI, MANDANA, & REZAEI, ABBAS. (2013). INHIBITORY ACTIVITY OF AVICENNIA MARINA, A MEDICINAL PLANT IN PERSIAN FOLK MEDICINE, AGAINST HIV AND HSV. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(2), 435-443. SID. https://sid.ir/paper/288155/en

Vancouver: Copy

NAMAZI RAHELE, ZABIHOLLAHI REZVAN, BEHBAHANI MANDANA, REZAEI ABBAS. INHIBITORY ACTIVITY OF AVICENNIA MARINA, A MEDICINAL PLANT IN PERSIAN FOLK MEDICINE, AGAINST HIV AND HSV. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(2):435-443. Available from: https://sid.ir/paper/288155/en

IEEE: Copy

RAHELE NAMAZI, REZVAN ZABIHOLLAHI, MANDANA BEHBAHANI, and ABBAS REZAEI, “INHIBITORY ACTIVITY OF AVICENNIA MARINA, A MEDICINAL PLANT IN PERSIAN FOLK MEDICINE, AGAINST HIV AND HSV,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 2, pp. 435–443, 2013, [Online]. Available: https://sid.ir/paper/288155/en

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