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Title

EVALUATION OF FENUGREEK (TRIGONELLA FOENUM-GRACEUM L.), EFFECTS SEEDS EXTRACT ON INSULIN RESISTANCE IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME

Pages

  475-481

Abstract

 PCOS (Polycystic Ovarian Syndrome) is associated with INSULIN RESISTANCE, obesity and disorders of lipid metabolism as well as infertility. FENUGREEK seeds extract is successfully used in lowering blood glucose. METFORMIN has also the same effect but in a different way. The aim of this study was the assessment of FENUGREEK effects on INSULIN RESISTANCE in women with PCOS.This was a prospective randomized, double-blind, placebo-controlled trial. The study was conducted at the Montaserieh Hospital in Mashhad University of Medical Sciences, Mashhad, Khorasan Razavi Province, Iran. The patient population included 58 oligo-anovulatory PCOS women with typical ovaries. Women were randomly allocated to receive hydroalcoholic extract of FENUGREEK seeds in capsules with METFORMIN (n=30) or placebo capsules with METFORMIN (n=28) and were assessed before and every 4 weeks within a treatment period of 8 weeks.Menstrual disturbance and metabolic parameters (markers of INSULIN RESISTANCE and hormonal parameters) were measured. INSULIN RESISTANCE based on HOMA-IR (homeostasis model assessment for INSULIN RESISTANCE) model was not significantly different between two groups. Ultrasound scans were performed before and at the end of 8 weeks treatment with significant decrease in PAO (polycystic appearing ovaries) in group 1 (p=0.01).Adjuvant therapy to the FENUGREEK seeds extract (with METFORMIN) in PCOS women improved the sonographic results and menstrual cyclicity.

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    APA: Copy

    HASSANZADEH BASHTIAN, MARYAM, EMAMI, SEYED AHMAD, MOUSAVIFAR, NEZHAT, ESMAILY, HABIB ALLAH, MAHMOUDI, MAHMOUD, & MOHAMMAD POOR, AMIR HOOSHANG. (2013). EVALUATION OF FENUGREEK (TRIGONELLA FOENUM-GRACEUM L.), EFFECTS SEEDS EXTRACT ON INSULIN RESISTANCE IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(2), 475-481. SID. https://sid.ir/paper/288162/en

    Vancouver: Copy

    HASSANZADEH BASHTIAN MARYAM, EMAMI SEYED AHMAD, MOUSAVIFAR NEZHAT, ESMAILY HABIB ALLAH, MAHMOUDI MAHMOUD, MOHAMMAD POOR AMIR HOOSHANG. EVALUATION OF FENUGREEK (TRIGONELLA FOENUM-GRACEUM L.), EFFECTS SEEDS EXTRACT ON INSULIN RESISTANCE IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(2):475-481. Available from: https://sid.ir/paper/288162/en

    IEEE: Copy

    MARYAM HASSANZADEH BASHTIAN, SEYED AHMAD EMAMI, NEZHAT MOUSAVIFAR, HABIB ALLAH ESMAILY, MAHMOUD MAHMOUDI, and AMIR HOOSHANG MOHAMMAD POOR, “EVALUATION OF FENUGREEK (TRIGONELLA FOENUM-GRACEUM L.), EFFECTS SEEDS EXTRACT ON INSULIN RESISTANCE IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 2, pp. 475–481, 2013, [Online]. Available: https://sid.ir/paper/288162/en

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