مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

301
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

105
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

CATECHOLAMINE CONTENTS OF DIFFERENT REGION OF ADULT RAT BRAIN ARE ALTERED FOLLOWING SHORT AND LONG-TERM EXPOSURES TO PB+2

Pages

  461-468

Keywords

PB+2 

Abstract

 Catecholamine is a group of neurotransmitters that is believed to be responsible for the normal function of animal brain. Physiological and behavioral changes of human body have been reported due to the damage of the brain function following LEAD exposure. Due to the assumption of LEAD disposal in brain tissue with two year for its half-life, which results in alteration of brain function, we investigated the ability of LEAD to change the brain CATECHOLAMINEs during short and long-term studies. Rats were exposed daily with varying amounts of LEAD and CATECHOLAMINE contents of cerebellum, mid-brain and brain cortex were determined.Acute peritoneal administration of single dose of LEAD as LEAD acetate (260 mmol/Kg) after 2 h reduced (p<0.05) the CATECHOLAMINE levels of cerebellum, mid-brain and cortex part by 34.9%, 35.44% and 23.8%, respectively. The extension of experiment time to 5 h, significant (p <0.05) reductions in CATECHOLAMINE levels of mentioned regions of brain by 32.35%, 12.35% and 19.3% were seen respectively. Daily intraperitoneal administration of 10 mmol/Kg LEAD for 30 and 60 days reduced CATECHOLAMINEs levels of cerebellum (22.22% and 30.44%), midbrain (12.48% and 26.27%) and brain cortex (11.58% and 26.7%) respectively. It might be concluded that brain dysfunction in LEAD intoxicated rat occurred through the reduction in the CATECHOLAMINE levels of different parts of brain. LEAD might be therefore considered as a probable factor in causing neurological disease in LEAD exposed man.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    MOSHTAGHIEA, MINOO, MALEKPOURI, PEDRAM, SAEED ZADEH, MOHAMMAD, MESSRIPOUR, MANUCHEHR, & MOSHTAGHIED, ALI ASGHAR. (2013). CATECHOLAMINE CONTENTS OF DIFFERENT REGION OF ADULT RAT BRAIN ARE ALTERED FOLLOWING SHORT AND LONG-TERM EXPOSURES TO PB+2. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 12(2), 461-468. SID. https://sid.ir/paper/288167/en

    Vancouver: Copy

    MOSHTAGHIEA MINOO, MALEKPOURI PEDRAM, SAEED ZADEH MOHAMMAD, MESSRIPOUR MANUCHEHR, MOSHTAGHIED ALI ASGHAR. CATECHOLAMINE CONTENTS OF DIFFERENT REGION OF ADULT RAT BRAIN ARE ALTERED FOLLOWING SHORT AND LONG-TERM EXPOSURES TO PB+2. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2013;12(2):461-468. Available from: https://sid.ir/paper/288167/en

    IEEE: Copy

    MINOO MOSHTAGHIEA, PEDRAM MALEKPOURI, MOHAMMAD SAEED ZADEH, MANUCHEHR MESSRIPOUR, and ALI ASGHAR MOSHTAGHIED, “CATECHOLAMINE CONTENTS OF DIFFERENT REGION OF ADULT RAT BRAIN ARE ALTERED FOLLOWING SHORT AND LONG-TERM EXPOSURES TO PB+2,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 12, no. 2, pp. 461–468, 2013, [Online]. Available: https://sid.ir/paper/288167/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button