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Information Journal Paper

Title

NON-AQUEOUS ELECTROMIGRATION ANALYSIS OF SOME DEGRADATION PRODUCTS OF CARVEDILOL

Pages

  471-486

Abstract

 A CAPILLARY ELECTROPHORESIS method was used for assay of some degradation products of CARVEDILOL. The optimized parameters were as; running buffer 80 mM acetate dissolved in methanol/ethanol mixture (65: 35% v/v), applied voltage of 19 kV, temperature is 20 ºC and the wavelength range of 200-350 nm. The results indicate that the proposed CAPILLARY ELECTROPHORESIS method could effectively separate CARVEDILOL from its degradation products and can be employed as a stability indicating assay method. In addition, the presence of a new unknown degradation product was discovered by this method. In addition, CAPILLARY ELECTROPHORESIS behaviour of CARVEDILOL in photo/force degradation conditions gave valuable information concerning the dissimilarities of their ionization. Results indicated that the proposed method can be used for the determination of CARVEDILOL in human serum. Finally, accuracy of the proposed method was established by recovery experiments from spiked human serum samples.

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    • Cite

    APA: Copy

    JOUYBAN, ABOLGHASEM, HASANZADEH, MOHAMMAD, & SHADJOU, NASRIN. (2014). NON-AQUEOUS ELECTROMIGRATION ANALYSIS OF SOME DEGRADATION PRODUCTS OF CARVEDILOL. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(2), 471-486. SID. https://sid.ir/paper/288215/en

    Vancouver: Copy

    JOUYBAN ABOLGHASEM, HASANZADEH MOHAMMAD, SHADJOU NASRIN. NON-AQUEOUS ELECTROMIGRATION ANALYSIS OF SOME DEGRADATION PRODUCTS OF CARVEDILOL. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2014;13(2):471-486. Available from: https://sid.ir/paper/288215/en

    IEEE: Copy

    ABOLGHASEM JOUYBAN, MOHAMMAD HASANZADEH, and NASRIN SHADJOU, “NON-AQUEOUS ELECTROMIGRATION ANALYSIS OF SOME DEGRADATION PRODUCTS OF CARVEDILOL,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 13, no. 2, pp. 471–486, 2014, [Online]. Available: https://sid.ir/paper/288215/en

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