HPTLC ANALYSIS, ANTIOXIDANT AND ANTIGOUT ACTIVITY OF INDIAN PLANTS

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NILE SHIVRAJ HARIRAM; PARK SE WON

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2014 | Volume:13 | Issue:2 Page(s): 531-539

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Information Journal Paper

Title

HPTLC ANALYSIS, ANTIOXIDANT AND ANTIGOUT ACTIVITY OF INDIAN PLANTS

Author(s)

NILE SHIVRAJ HARIRAM | PARK SE WON | Issue Writer Certificate

Keywords

HPTLC

MEDICINAL PLANTS

XANTHINE OXIDASE

ANTIOXIDANT

FLAVONOIDS

Abstract

The HPTLC analysis, ANTIOXIDANT, and antigout activity of Asparagus racemosus, Withania somnifera, Vitex negundo, Plumbago zeylanica, Butea monosperma and Tephrosia purpurea extracts were investigated. The chemical fingerprinting were carried out by high performance thin layer chromatography (HPTLC), ANTIOXIDANT activity by ABTS, DPPH, FRAP radical scavenging assays, and antiogout activity by cow milk XANTHINE OXIDASE. The HPTLC fingerprint qualitatively revealed predominant amount of FLAVONOIDS. The TEAC values ranged from 45.80 to 140 mM trolox/100 g dry weight for ABTS, from 85 to 430 mM trolox/ 100 g dw DPPH, and 185 to 560 mM trolox/100 g dw for FRAP respectively. Plants used in this study was found to inhibit the toxicity, as seen from the decreased LPO and increased GSH, SOD and CAT levels. The total phenolic and flavonoid content ranged from 10.21 to 28.17 and 5.80 to 10.1 mg of gallic acid equivalents (GAE) /100 gdw respectively. The plant extracts demonstrated significant XANTHINE OXIDASE inhibitory activity at 100 g/mL and revealed an inhibition greater than 50% and IC50 values below the standard. This effect was almost similar to the activity of allopurinol (Standard drug) against XANTHINE OXIDASE (90.2±0.4 %). These plant root extract will be subjected for further extensive studies to isolate and identify their active constituents which are useful for against inflammation and gout.

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APA: Copy

NILE, SHIVRAJ HARIRAM, & PARK, SE WON. (2014). HPTLC ANALYSIS, ANTIOXIDANT AND ANTIGOUT ACTIVITY OF INDIAN PLANTS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(2), 531-539. SID. https://sid.ir/paper/288220/en

Vancouver: Copy

NILE SHIVRAJ HARIRAM, PARK SE WON. HPTLC ANALYSIS, ANTIOXIDANT AND ANTIGOUT ACTIVITY OF INDIAN PLANTS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2014;13(2):531-539. Available from: https://sid.ir/paper/288220/en

IEEE: Copy

SHIVRAJ HARIRAM NILE, and SE WON PARK, “HPTLC ANALYSIS, ANTIOXIDANT AND ANTIGOUT ACTIVITY OF INDIAN PLANTS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 13, no. 2, pp. 531–539, 2014, [Online]. Available: https://sid.ir/paper/288220/en

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