مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

308
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

99
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

IMBALANCED DIET DEFICIENT IN CALCIUM AND VITAMIN D- INDUCED JUVENILE OSTEOPENIA IN RATS; THE POTENTIAL THERAPEUTIC EFFECT OF EGYPTIAN MOGHAT ROOTS WATER EXTRACT (GLOSSOSTEMON BRUGUIERI)

Pages

  623-634

Abstract

 This study aimed to explore and validate a new juvenile osteopenic (JO) rat model then examine the efficacy of moghat (Glossostemon bruguieri) as an alternative reversal therapy for JO. Phytochemical screening analysis showed that moghat contains 5.8% alkaloids, 1.5% flavonoids and 13.2% total phenols. JUVENILE OSTEOPENIA was induced in 15 days old Sprague- Dawley female rats by feeding them free Ca and vitamin D synthetic diet for 21 days. Osteopenic rats were either treated with moghat (0.8 g dried plant tissue/Kg body weight, orally), or with a reference nutritional supplements of calcium chloride (14 mg Ca/Kg) and vitamin D3 (7 IU/ Kg), for extra 21 days. Both untreated and treated groups were compared to a control group that fed a regular pelleted food. Our results showed that osteopenic rats lost normal bone tissue architecture, 30 % of body mass, 54 % of bone mass and finally 93% of bone calcium mass. Furthermore, these rats showed a markedly increase in serum phosphate, PTH, alkaline phosphatase, aspartate transaminase activities and creatinine level as compared to the control group. Moghat administration was successfully reversed osteopenia by normalizing body and bone masses to the reference ranges, increased the bone calcium mass by 17 fold without any detectable side effects on liver and kidney physiological performance. Therefore, moghat could be considered as potent safe –JO- reversal extract.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    GHAREEB, DOAA A., EL RASHIDY, FATMA H., & EL MALLAWANY, SHERIF. (2014). IMBALANCED DIET DEFICIENT IN CALCIUM AND VITAMIN D- INDUCED JUVENILE OSTEOPENIA IN RATS; THE POTENTIAL THERAPEUTIC EFFECT OF EGYPTIAN MOGHAT ROOTS WATER EXTRACT (GLOSSOSTEMON BRUGUIERI). IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(2), 623-634. SID. https://sid.ir/paper/288229/en

    Vancouver: Copy

    GHAREEB DOAA A., EL RASHIDY FATMA H., EL MALLAWANY SHERIF. IMBALANCED DIET DEFICIENT IN CALCIUM AND VITAMIN D- INDUCED JUVENILE OSTEOPENIA IN RATS; THE POTENTIAL THERAPEUTIC EFFECT OF EGYPTIAN MOGHAT ROOTS WATER EXTRACT (GLOSSOSTEMON BRUGUIERI). IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2014;13(2):623-634. Available from: https://sid.ir/paper/288229/en

    IEEE: Copy

    DOAA A. GHAREEB, FATMA H. EL RASHIDY, and SHERIF EL MALLAWANY, “IMBALANCED DIET DEFICIENT IN CALCIUM AND VITAMIN D- INDUCED JUVENILE OSTEOPENIA IN RATS; THE POTENTIAL THERAPEUTIC EFFECT OF EGYPTIAN MOGHAT ROOTS WATER EXTRACT (GLOSSOSTEMON BRUGUIERI),” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 13, no. 2, pp. 623–634, 2014, [Online]. Available: https://sid.ir/paper/288229/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button