N-(5-MERCAPTO-1,3,4-THIADIAZOL-2-YL)-2-PHENYLACETAMIDE DERIVATIVES: SYNTHESIS AND IN-VITRO CYTOTOXICITY EVALUATION AS POTENTIAL ANTICANCER AGENTS

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MOHAMMADI FARANIA AHMAD; HEIDARIAN NEDA; ALIABADI ALIREZA

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2014 | Volume:13 | Issue:2 Page(s): 487-492

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Information Journal Paper

Title

N-(5-MERCAPTO-1,3,4-THIADIAZOL-2-YL)-2-PHENYLACETAMIDE DERIVATIVES: SYNTHESIS AND IN-VITRO CYTOTOXICITY EVALUATION AS POTENTIAL ANTICANCER AGENTS

Author(s)

MOHAMMADI FARANIA AHMAD | HEIDARIAN NEDA | ALIABADI ALIREZA | Issue Writer Certificate

Keywords

SYNTHESIS

4-THIADIAZOLE

ANTICANCER

AMIDATION

Abstract

A new series of N- (5-Mercapto-1, 3, 4-thiadiazol-2-yl) -2-phenylacetamide derivatives (3a- 3j) were synthesized via an AMIDATION reaction using EDC and HOBt in acetonitrile solvent at room temperature condition. Chemical structures were characterized by H NMR, IR and MS spectroscopic methods and related melting points were also determined. The ANTICANCER activity was evaluated using MTT procedure in-vitro. All compounds were tested against SKNMC (Neuroblastoma), HT-29 (Colon cancer) and PC3 (Prostate cancer) cell lines. According to the toxicological data, none of the synthesized derivatives exerted superior activity than doxorubicin as reference drug. Derivatives with Ortho chlorine (compound 3d), meta methoxy (compound 3h) and meta fluorine (compound 3b) substituents on the phenyl ring exhibited the best cytotoxic activity against SKNMC (IC50=4.5±0.035 mM), HT-29 (IC50=3.1±0.030 mM) and PC3 (IC50=12.6±0.302 mM) cell lines respectively.

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APA: Copy

MOHAMMADI FARANIA, AHMAD, HEIDARIAN, NEDA, & ALIABADI, ALIREZA. (2014). N-(5-MERCAPTO-1,3,4-THIADIAZOL-2-YL)-2-PHENYLACETAMIDE DERIVATIVES: SYNTHESIS AND IN-VITRO CYTOTOXICITY EVALUATION AS POTENTIAL ANTICANCER AGENTS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(2), 487-492. SID. https://sid.ir/paper/288233/en

Vancouver: Copy

MOHAMMADI FARANIA AHMAD, HEIDARIAN NEDA, ALIABADI ALIREZA. N-(5-MERCAPTO-1,3,4-THIADIAZOL-2-YL)-2-PHENYLACETAMIDE DERIVATIVES: SYNTHESIS AND IN-VITRO CYTOTOXICITY EVALUATION AS POTENTIAL ANTICANCER AGENTS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2014;13(2):487-492. Available from: https://sid.ir/paper/288233/en

IEEE: Copy

AHMAD MOHAMMADI FARANIA, NEDA HEIDARIAN, and ALIREZA ALIABADI, “N-(5-MERCAPTO-1,3,4-THIADIAZOL-2-YL)-2-PHENYLACETAMIDE DERIVATIVES: SYNTHESIS AND IN-VITRO CYTOTOXICITY EVALUATION AS POTENTIAL ANTICANCER AGENTS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 13, no. 2, pp. 487–492, 2014, [Online]. Available: https://sid.ir/paper/288233/en

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