ANTI-VIRAL EVALUATION OF SESQUITERPENE COUMARINS FROM FERULA ASSA-FOETIDA AGAINST HSV-1

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GHANNADI ALIREZA; FATTAHIAN KHADIJEH; SHOKOOHINIA YALDA; BEHBAHANI MANDANA; SHAHNOUSH ALIREZA

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Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2014 | Volume:13 | Issue:2 Page(s): 523-530

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Title

ANTI-VIRAL EVALUATION OF SESQUITERPENE COUMARINS FROM FERULA ASSA-FOETIDA AGAINST HSV-1

Author(s)

Keywords

KELLERIN

BADRAKEMIN ACETATE

SAMARCANDIN DIASTEREOMER

FERULA ASSA-FOETIDA

HERPES SIMPLEX

Abstract

Several complications attributed with Herpes virus related infections and the emergence of drug resistant viruses prompt scientists to search for new drugs. Several terpenoids and coumarins have shown anti HSV effects while no sesquiterpene coumarins have been previously tested for HSV treatment. Three sesquiterpene coumarins BADRAKEMIN ACETATE (1), KELLERIN (2) and SAMARCANDIN DIASTEREOMER (3) were isolated from the gum resin of FERULA ASSA-FOETIDA, a herbal medicine with antimicrobial, antiprotozoal and antiviral effects. Compounds were identified by 1D and 2D- NMR spectroscopies and comparison with literature data. A comparative evaluation of cytotoxicity and antiviral activity showed that KELLERIN (2) could significantly inhibit the cytopathic effects and reduce the viral titre of the herpes virus type 1 (HSV-1) DNA viral strain KOS at concentrations of 10, 5 and 2.5 mg/mL.

Cites

ISOLATION AND DETERMINATION OF CUMARIN CONSTITUENT"AURAPTEN" FROMFERULA PERSICA VAR. LATISECTA AN ENDEMIC MEDICINAL PLANT OF IRAN

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APA: Copy

GHANNADI, ALIREZA, FATTAHIAN, KHADIJEH, SHOKOOHINIA, YALDA, BEHBAHANI, MANDANA, & SHAHNOUSH, ALIREZA. (2014). ANTI-VIRAL EVALUATION OF SESQUITERPENE COUMARINS FROM FERULA ASSA-FOETIDA AGAINST HSV-1. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(2), 523-530. SID. https://sid.ir/paper/288234/en

Vancouver: Copy

GHANNADI ALIREZA, FATTAHIAN KHADIJEH, SHOKOOHINIA YALDA, BEHBAHANI MANDANA, SHAHNOUSH ALIREZA. ANTI-VIRAL EVALUATION OF SESQUITERPENE COUMARINS FROM FERULA ASSA-FOETIDA AGAINST HSV-1. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2014;13(2):523-530. Available from: https://sid.ir/paper/288234/en

IEEE: Copy

ALIREZA GHANNADI, KHADIJEH FATTAHIAN, YALDA SHOKOOHINIA, MANDANA BEHBAHANI, and ALIREZA SHAHNOUSH, “ANTI-VIRAL EVALUATION OF SESQUITERPENE COUMARINS FROM FERULA ASSA-FOETIDA AGAINST HSV-1,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 13, no. 2, pp. 523–530, 2014, [Online]. Available: https://sid.ir/paper/288234/en

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