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Information Journal Paper

Title

COMPARISON OF THE EFFECTS OF ENOXAPARIN AND HEPARIN ON INFLAMMATORY BIOMARKERS IN PATIENTS WITH ST-SEGMENT ELEVATED MYOCARDIAL INFARCTION: A PROSPECTIVE OPEN LABEL PILOT CLINICAL TRIAL

Pages

  583-590

Abstract

 HEPARIN and ENOXAPARIN possess anti-inflammatory properties. We compared the effects of these drugs on INFLAMMATORY BIOMARKERS in patients with ST-segment Elevated Myocardial Infarction (STEMI).Thirty four patients with STEMI randomly separated in two groups and received standard doses of HEPARIN and ENOXAPARIN. The serum concentration of Serum Amyloid A (SAA), C-Reactive Protein (CRP), Interleukin (IL) -6, ferritin and Myeloperoxidase (MPO) were measured at baseline, 12, 24 and 48 hours after drug administration.Serum concentrations of SAA (P: 0.02), CRP (P: 0.02) and ferritin (P: 0.01) significantly reduced in HEPARIN group during measurements compared to baseline, circulating levels of IL-6 (P: 0.002), SAA (P: 0.009), CRP (P: 0.01) were significantly decreased in ENOXAPARIN group. The overall difference in INFLAMMATORY BIOMARKERS between HEPARIN and ENOXAPARIN group was not significant.Both HEPARIN and ENOXAPARINe reduced serum levels of INFLAMMATORY BIOMARKERS in patients with STEMI. This effect may provide additional clinical benefit of these drugs in the treatment of STEMI patients.

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    APA: Copy

    NASIRIPOUR, SOMAYYEH, GHOLAMI, KHEIROLLAH, MOUSAVI, SARAH, MOHAGHEGHI, ABBAS, RADFAR, MANIA, ABDOLLAHI, MOHAMMAD, KHAZAEIPOUR, ZAHRA, & MOJTAHEDZADEH, MOJTABA. (2014). COMPARISON OF THE EFFECTS OF ENOXAPARIN AND HEPARIN ON INFLAMMATORY BIOMARKERS IN PATIENTS WITH ST-SEGMENT ELEVATED MYOCARDIAL INFARCTION: A PROSPECTIVE OPEN LABEL PILOT CLINICAL TRIAL. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(2), 583-590. SID. https://sid.ir/paper/288237/en

    Vancouver: Copy

    NASIRIPOUR SOMAYYEH, GHOLAMI KHEIROLLAH, MOUSAVI SARAH, MOHAGHEGHI ABBAS, RADFAR MANIA, ABDOLLAHI MOHAMMAD, KHAZAEIPOUR ZAHRA, MOJTAHEDZADEH MOJTABA. COMPARISON OF THE EFFECTS OF ENOXAPARIN AND HEPARIN ON INFLAMMATORY BIOMARKERS IN PATIENTS WITH ST-SEGMENT ELEVATED MYOCARDIAL INFARCTION: A PROSPECTIVE OPEN LABEL PILOT CLINICAL TRIAL. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2014;13(2):583-590. Available from: https://sid.ir/paper/288237/en

    IEEE: Copy

    SOMAYYEH NASIRIPOUR, KHEIROLLAH GHOLAMI, SARAH MOUSAVI, ABBAS MOHAGHEGHI, MANIA RADFAR, MOHAMMAD ABDOLLAHI, ZAHRA KHAZAEIPOUR, and MOJTABA MOJTAHEDZADEH, “COMPARISON OF THE EFFECTS OF ENOXAPARIN AND HEPARIN ON INFLAMMATORY BIOMARKERS IN PATIENTS WITH ST-SEGMENT ELEVATED MYOCARDIAL INFARCTION: A PROSPECTIVE OPEN LABEL PILOT CLINICAL TRIAL,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 13, no. 2, pp. 583–590, 2014, [Online]. Available: https://sid.ir/paper/288237/en

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