ACUTE TOXICITY INVESTIGATION AND ANTI-DIARRHOEAL EFFECT OF THE CHLOROFORM-METHANOL EXTRACT OF THE LEAVES OF PERSEA AMERICANA

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ODO CHRISTIAN E.; NWODO OKWESILI FC; JOSHUA PARKER E.; UGWU OKECHUKWU PC

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2014 | Volume:13 | Issue:2 Page(s): 651-658

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Title

ACUTE TOXICITY INVESTIGATION AND ANTI-DIARRHOEAL EFFECT OF THE CHLOROFORM-METHANOL EXTRACT OF THE LEAVES OF PERSEA AMERICANA

Author(s)

ODO CHRISTIAN E. | NWODO OKWESILI FC | JOSHUA PARKER E. | UGWU OKECHUKWU PC | Issue Writer Certificate

Keywords

LURACEAE

ACUTE TOXICITY

ENTEROPOOLING

HYOSCINE BUTYLBROMIDE

INTESTINAL CONTENTS

Abstract

Persea americana is a plant used by traditional medicine practitioners to treat ailments including diarrhoea and diabetes mellitus in Nigeria. Hence, the chloroform and the methanol fractions of the chloroform-methanol extract of the leaves of P. americana were evaluated for their ACUTE TOXICITY as well as anti-diarrhoeal effects in Wistar rats to substantiate this claim. The chloroform and methanol fractions [at graded doses of 100 and 200 mg/Kg body weight (b.w) of each] were studied for their anti-diarrhoeal effects in terms of the reductions in the wetness of faeces and the frequency of defaecation of castor oil-induced diarrhoea. To understand the mechanism of their anti-diarrhoeal effects, their actions were further evaluated on castor oil-induced ENTEROPOOLING (intestinal fluid accumulation). The median lethal dose (LD50) of the methanol fraction was found to be less than 5000 mg/Kg b.w. At the two doses, the chloroform and the methanol fractions showed dose-dependent significant (p<0.05) reductions in the wetness of faeces and the frequency of defaecation with the 200 mg/Kg b.w of the chloroform fraction being the most effective. Results of the fractions were comparable with those of the standard anti-diarrhoeal drug, HYOSCINE BUTYLBROMIDE (3 mg/Kg b.w). Both fractions produced remarkable (p<0.05) dose-related inhibition of castor oil-induced ENTEROPOOLING as shown by the significant (p<0.05) decreases in the weight and volume of the INTESTINAL CONTENTS. Experimental findings show that the chloroform-methanol extract of the leaves of P. americana possesses significant anti-diarrhoeal effect and may be a potent source of anti-diarrhoeal drug (s) in future.

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APA: Copy

ODO CHRISTIAN, E., NWODO OKWESILI, FC, JOSHUA PARKER, E., & UGWU OKECHUKWU, PC. (2014). ACUTE TOXICITY INVESTIGATION AND ANTI-DIARRHOEAL EFFECT OF THE CHLOROFORM-METHANOL EXTRACT OF THE LEAVES OF PERSEA AMERICANA. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(2), 651-658. SID. https://sid.ir/paper/288246/en

Vancouver: Copy

ODO CHRISTIAN E., NWODO OKWESILI FC, JOSHUA PARKER E., UGWU OKECHUKWU PC. ACUTE TOXICITY INVESTIGATION AND ANTI-DIARRHOEAL EFFECT OF THE CHLOROFORM-METHANOL EXTRACT OF THE LEAVES OF PERSEA AMERICANA. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2014;13(2):651-658. Available from: https://sid.ir/paper/288246/en

IEEE: Copy

E. ODO CHRISTIAN, FC NWODO OKWESILI, E. JOSHUA PARKER, and PC UGWU OKECHUKWU, “ACUTE TOXICITY INVESTIGATION AND ANTI-DIARRHOEAL EFFECT OF THE CHLOROFORM-METHANOL EXTRACT OF THE LEAVES OF PERSEA AMERICANA,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 13, no. 2, pp. 651–658, 2014, [Online]. Available: https://sid.ir/paper/288246/en

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