A POSSIBLE NON-GENOMIC EPILEPTOGENIC PROPERTIES OF ESTRADIOL ATTENUATED BY MK801 AND DNQX IN AMYGDALA KINDLED RATS

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SABERI MEHDI; SABERI FATEMEH; VESALI MAHMOUD ROSHANAK

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2014 | Volume:13 | Issue:3 Page(s): 987-993

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Title

A POSSIBLE NON-GENOMIC EPILEPTOGENIC PROPERTIES OF ESTRADIOL ATTENUATED BY MK801 AND DNQX IN AMYGDALA KINDLED RATS

Author(s)

SABERI MEHDI | SABERI FATEMEH | VESALI MAHMOUD ROSHANAK | Issue Writer Certificate

Keywords

MALE RATS

AMYGDALAKINDLING

SEIZURE

ESTRADIOL BENZOATE

MK801

DNQX

Abstract

Although the epileptogenic properties of estrogens have been widely demonstrated in several models and species, the mechanism (s) by which estrogens can acutely change SEIZURE parameters including after discharge and SEIZURE durationremains to be determined. In the present study, we examined the role of NMDA (N-methyl-D-aspartate), non-NMDA andestrogen receptors in ESTRADIOL BENZOATE (EB) effects on kindled SEIZURE parameters.Different groups of fully kindled MALE RATS received either EB (30 mg /Kg); EB plus MK801 (2 mg/Kg, as NMDA antagonist); DNQX (7.5 mg/Kg); tamoxifen (TAM, 0.1 mg/Kg, as non- NMDA antagonist) or intra-amygdala injection of anisomycine (30 mmol/mL, a protein synthesis inhibitor). Kindled SEIZURE parameters including after discharge duration (ADD) and stage 5 duration (S5D) were determined at 0.25 and 3 h post sesame oil (EB solvent) or EB treatment.While pretreatment with either MK801 or DNQX could block the ADD prolongation induced by EB at 0.25 h, they had no effect on S5D prolongation at 3 h. Moreover, application of anisomycine or TAM had no effect on estradiol induced ADD and S5D prolongation. These results indicate that both NMDA and non-NMDA receptors could be involved in EB induced ADD prolongation. The observed short termnon-estrogenic receptor or protein synthesis dependent effects of EB may provide a non-genomic mechanism for the stimulatory effects of the steroid on SEIZURE activity.

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APA: Copy

SABERI, MEHDI, SABERI, FATEMEH, & VESALI MAHMOUD, ROSHANAK. (2014). A POSSIBLE NON-GENOMIC EPILEPTOGENIC PROPERTIES OF ESTRADIOL ATTENUATED BY MK801 AND DNQX IN AMYGDALA KINDLED RATS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(3), 987-993. SID. https://sid.ir/paper/288266/en

Vancouver: Copy

SABERI MEHDI, SABERI FATEMEH, VESALI MAHMOUD ROSHANAK. A POSSIBLE NON-GENOMIC EPILEPTOGENIC PROPERTIES OF ESTRADIOL ATTENUATED BY MK801 AND DNQX IN AMYGDALA KINDLED RATS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2014;13(3):987-993. Available from: https://sid.ir/paper/288266/en

IEEE: Copy

MEHDI SABERI, FATEMEH SABERI, and ROSHANAK VESALI MAHMOUD, “A POSSIBLE NON-GENOMIC EPILEPTOGENIC PROPERTIES OF ESTRADIOL ATTENUATED BY MK801 AND DNQX IN AMYGDALA KINDLED RATS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 13, no. 3, pp. 987–993, 2014, [Online]. Available: https://sid.ir/paper/288266/en

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