A RAPID AND SENSITIVE HPLC-FLUORESCENCE METHOD FOR DETERMINATION OF MIRTAZAPINE AND ITS TWO MAJOR METABOLITES IN HUMAN PLASMA

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LAVASANI HODA; GIORGI MARIO; SHEIKHOLESLAMI BEHJAT; HEDAYATI MOHAMMADHASAN; ROUINI MOHAMMAD REZA

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2014 | Volume:13 | Issue:3 Page(s): 853-862

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Title

A RAPID AND SENSITIVE HPLC-FLUORESCENCE METHOD FOR DETERMINATION OF MIRTAZAPINE AND ITS TWO MAJOR METABOLITES IN HUMAN PLASMA

Author(s)

Keywords

MIRTAZAPINE

METABOLITES

HPLC

PLASMA

FLUORESCENCE

Abstract

A rapid and sensitive HPLC method has been developed for the quantification of MIRTAZAPINE (MRZ), a noradrenergic and specific serotonergic inhibitor antidepressant (NaSSA) and its two major METABOLITES N-desmethyl MIRTAZAPINE (NDM) and 8-hydroxyMIRTAZAPINE (8-OHM) in human PLASMA.The separation was achieved using Chromolith C18 column and a mobile phase of acetonitrile: phosphate buffer (pH = 3, 20:80, v/v) in isocratic mode at a flow rate of 2 mL/min. A FLUORESCENCE detector was set at 290 and 350 nm for excitation and emission, respectively. Zolpidem was used as the internal standard. Liquid-liquid extraction was applied for sample clean up. All analytes were eluted in less than 5 minutes with LOQ of 1 ng/mL for MRZ and 2 ng/mL for both NDM and 8-OHM. The developed method was successfully applied to quantify MRZ and its METABOLITES in PLASMA of a healthy volunteer.

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APA: Copy

LAVASANI, HODA, GIORGI, MARIO, SHEIKHOLESLAMI, BEHJAT, HEDAYATI, MOHAMMADHASAN, & ROUINI, MOHAMMAD REZA. (2014). A RAPID AND SENSITIVE HPLC-FLUORESCENCE METHOD FOR DETERMINATION OF MIRTAZAPINE AND ITS TWO MAJOR METABOLITES IN HUMAN PLASMA. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(3), 853-862. SID. https://sid.ir/paper/288273/en

Vancouver: Copy

LAVASANI HODA, GIORGI MARIO, SHEIKHOLESLAMI BEHJAT, HEDAYATI MOHAMMADHASAN, ROUINI MOHAMMAD REZA. A RAPID AND SENSITIVE HPLC-FLUORESCENCE METHOD FOR DETERMINATION OF MIRTAZAPINE AND ITS TWO MAJOR METABOLITES IN HUMAN PLASMA. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2014;13(3):853-862. Available from: https://sid.ir/paper/288273/en

IEEE: Copy

HODA LAVASANI, MARIO GIORGI, BEHJAT SHEIKHOLESLAMI, MOHAMMADHASAN HEDAYATI, and MOHAMMAD REZA ROUINI, “A RAPID AND SENSITIVE HPLC-FLUORESCENCE METHOD FOR DETERMINATION OF MIRTAZAPINE AND ITS TWO MAJOR METABOLITES IN HUMAN PLASMA,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 13, no. 3, pp. 853–862, 2014, [Online]. Available: https://sid.ir/paper/288273/en

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