EVALUATION OF PROTECTIVE EFFICACY OF AVICENNIA MARINA (FORSSK.) VIERH LEAVES AGAINST COMPLETE FREUND'S ADJUVANT-INDUCED ARTHRITIS IN WISTAR

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ZAMANI GANDOMANI MAHDI; FOROUZANDEH MALATI ELAHEH

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2014 | Volume:13 | Issue:3 Page(s): 945-951

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Information Journal Paper

Title

EVALUATION OF PROTECTIVE EFFICACY OF AVICENNIA MARINA (FORSSK.) VIERH LEAVES AGAINST COMPLETE FREUND'S ADJUVANT-INDUCED ARTHRITIS IN WISTAR

Author(s)

ZAMANI GANDOMANI MAHDI | FOROUZANDEH MALATI ELAHEH | Issue Writer Certificate

Keywords

AVICENNIA MARINA

COMPLETE FREUND'S ADJUVANT

WISTAR RAT

Abstract

Aviecennia marina (Avicenniaceae) is an endemic plant that widely distributed in the Southern parts of Iran. This plant has been used as treatment of rheumatism arthritis among the inhabitants of Southern parts of Iran. The AVICENNIA MARINA hydroalcoholic extract was prepared and its protective efficacy was investigated using measurement of ankle diameter, total WBC and RBC count, ESR, and Pro-inflammatory cytokines levels in the COMPLETE FREUND'S ADJUVANT (CFA) -induced arthritic rat. The increment in ESR and total WBC, reduction in RBC count and hemoglobin levels observed in the arthritic animals were also found to be significantly restored in HEA treated rats. A. marina at 400 mg/Kg significantly decreases the serum pro-inflammatory cytokines as well as normalizes ankle diameter of CFA rats. A. marina (400 mg/Kg) significantly normalizes changes observed in arthritic rats to near normal conditions, indicates that A. marina has promising protective efficacy against arthritic rats.

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APA: Copy

ZAMANI GANDOMANI, MAHDI, & FOROUZANDEH MALATI, ELAHEH. (2014). EVALUATION OF PROTECTIVE EFFICACY OF AVICENNIA MARINA (FORSSK.) VIERH LEAVES AGAINST COMPLETE FREUND'S ADJUVANT-INDUCED ARTHRITIS IN WISTAR. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(3), 945-951. SID. https://sid.ir/paper/288277/en

Vancouver: Copy

ZAMANI GANDOMANI MAHDI, FOROUZANDEH MALATI ELAHEH. EVALUATION OF PROTECTIVE EFFICACY OF AVICENNIA MARINA (FORSSK.) VIERH LEAVES AGAINST COMPLETE FREUND'S ADJUVANT-INDUCED ARTHRITIS IN WISTAR. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2014;13(3):945-951. Available from: https://sid.ir/paper/288277/en

IEEE: Copy

MAHDI ZAMANI GANDOMANI, and ELAHEH FOROUZANDEH MALATI, “EVALUATION OF PROTECTIVE EFFICACY OF AVICENNIA MARINA (FORSSK.) VIERH LEAVES AGAINST COMPLETE FREUND'S ADJUVANT-INDUCED ARTHRITIS IN WISTAR,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 13, no. 3, pp. 945–951, 2014, [Online]. Available: https://sid.ir/paper/288277/en

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