THE BIOLOGICAL ACTIVITY AND COMPOSITION OF THE ESSENTIAL OIL OF SCLERORHACHIS LEPTOCLADA (ASTERACEAE-ANTHEMIDEAE) FROM IRAN

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SONBOLI ALI; MIRJALILI MOHAMMAD HOSSEIN; HADIAN JAVAD; YOUSEFZADI MORTEZA

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2014 | Volume:13 | Issue:3 Page(s): 1097-1104

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Title

THE BIOLOGICAL ACTIVITY AND COMPOSITION OF THE ESSENTIAL OIL OF SCLERORHACHIS LEPTOCLADA (ASTERACEAE-ANTHEMIDEAE) FROM IRAN

Author(s)

SONBOLI ALI | MIRJALILI MOHAMMAD HOSSEIN | HADIAN JAVAD | YOUSEFZADI MORTEZA | Issue Writer Certificate

Keywords

SCLERORHACHIS

VOLATILE OIL

ANTIBACTERIAL

ANTICANCER

Abstract

The biological activity and composition of the essential oil of SCLERORHACHIS leptoclada Rech. f. an endemic species from northeast of Iran was studied. The essential oil was isolated from the aerial flowering parts of the plant and analyzed by GC and GC-MS. Fifty-four compounds accounting for 95.9% of the total oil were characterized. The main constituents were (E)-nerolidol (14.5%), terpinen-4-ol (13.3%), camphor (6.1%), 1,8-cineole (4.8%) and p-cymene (4.5%). The antimicrobial activity of the essential oil of S. leptoclada was tested against eight microbial strains and a fungi. The results of the bioassays showed that the Grampositive bacteria, Bacillus subtilis and Staphylococcus epidermidis, were the most sensitive to the oil than others with the MIC value of 1.8 mg/mL. The tested fungi, Saccharomyces cerevisiae was highly inhibited by the oil of S. leptoclada with MIC value of 10 mg/mL. In the case of cytotoxicity, IC50 values estimated to be 312, 1250, 625 and 1250 mg oil/mL respectively, for the Vero, SW480, MCF7, and JET 3 cancer cell lines.

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APA: Copy

SONBOLI, ALI, MIRJALILI, MOHAMMAD HOSSEIN, HADIAN, JAVAD, & YOUSEFZADI, MORTEZA. (2014). THE BIOLOGICAL ACTIVITY AND COMPOSITION OF THE ESSENTIAL OIL OF SCLERORHACHIS LEPTOCLADA (ASTERACEAE-ANTHEMIDEAE) FROM IRAN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(3), 1097-1104. SID. https://sid.ir/paper/288281/en

Vancouver: Copy

SONBOLI ALI, MIRJALILI MOHAMMAD HOSSEIN, HADIAN JAVAD, YOUSEFZADI MORTEZA. THE BIOLOGICAL ACTIVITY AND COMPOSITION OF THE ESSENTIAL OIL OF SCLERORHACHIS LEPTOCLADA (ASTERACEAE-ANTHEMIDEAE) FROM IRAN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2014;13(3):1097-1104. Available from: https://sid.ir/paper/288281/en

IEEE: Copy

ALI SONBOLI, MOHAMMAD HOSSEIN MIRJALILI, JAVAD HADIAN, and MORTEZA YOUSEFZADI, “THE BIOLOGICAL ACTIVITY AND COMPOSITION OF THE ESSENTIAL OIL OF SCLERORHACHIS LEPTOCLADA (ASTERACEAE-ANTHEMIDEAE) FROM IRAN,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 13, no. 3, pp. 1097–1104, 2014, [Online]. Available: https://sid.ir/paper/288281/en

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