PREPARATION, PHYSICOCHEMICAL CHARACTERIZATION AND IN-VITRO DISSOLUTION STUDIES OF DIOSMIN-CYCLODEXTRIN INCLUSION COMPLEXES

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AI FENGWEI; MA YINGLI; WANG JIAYU; LI YANFENG

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2014 | Volume:13 | Issue:4 Page(s): 1115-1123

Download Full-Text

View:

688

Download:

144

Cites:

Information Journal Paper

Title

PREPARATION, PHYSICOCHEMICAL CHARACTERIZATION AND IN-VITRO DISSOLUTION STUDIES OF DIOSMIN-CYCLODEXTRIN INCLUSION COMPLEXES

Author(s)

AI FENGWEI | MA YINGLI | WANG JIAYU | LI YANFENG | Issue Writer Certificate

Keywords

DIOSMIN

CYCLODEXTRINS

SOLUBILITY

INCLUSION COMPLEX

DISSOLUTION RATE

Abstract

DIOSMIN, a vascular-protecting agent, is practically insoluble in water, and its oral absorption is limited by its extremely low DISSOLUTION RATE. In this study, b-cyclodextrin (bCD) and 2-hydroxypropyl-b-cyclodextrin (HPbCD) were obtained to improve the SOLUBILITY and DISSOLUTION RATE of DIOSMIN. Phase SOLUBILITY studies of DIOSMIN with bCD and HPbCD in distilled water were conducted to characterize the complexes in liquid state. The solidstate characterization of the complexes prepared with different methods was performed by fourier transform-infra red spectroscopy (FTIR), optical microscopy analyses, and differential scanning calorimetry (DSC). Dissolution studies were carried out in distilled water using US pharmacopeia DISSOLUTION RATE testing equipment. The complexation of DIOSMIN with bCD and HPbCD both indicated an AL type of phase-solubility diagrams, and the apparent stability constants (Kc) was found to be 222.13 and 200.08 M-1, respectively. The Kc values indicated the bCD and HPbCD showed the similar equal complexation ability with DIOSMIN, HPbCD provided higher SOLUBILITY for DIOSMIN due to its higher water SOLUBILITY. The dissolution studies suggest that the INCLUSION COMPLEXes provide higher DISSOLUTION RATE compared with the physical mixtures and the drug alone. Furthermore, the INCLUSION COMPLEX prepared by freeze drying method presented higher DISSOLUTION RATE than kneading method.

Cites

No record.

References

No record.

Cite

APA: Copy

AI, FENGWEI, MA, YINGLI, WANG, JIAYU, & LI, YANFENG. (2014). PREPARATION, PHYSICOCHEMICAL CHARACTERIZATION AND IN-VITRO DISSOLUTION STUDIES OF DIOSMIN-CYCLODEXTRIN INCLUSION COMPLEXES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(4), 1115-1123. SID. https://sid.ir/paper/288321/en

Vancouver: Copy

AI FENGWEI, MA YINGLI, WANG JIAYU, LI YANFENG. PREPARATION, PHYSICOCHEMICAL CHARACTERIZATION AND IN-VITRO DISSOLUTION STUDIES OF DIOSMIN-CYCLODEXTRIN INCLUSION COMPLEXES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2014;13(4):1115-1123. Available from: https://sid.ir/paper/288321/en

IEEE: Copy

FENGWEI AI, YINGLI MA, JIAYU WANG, and YANFENG LI, “PREPARATION, PHYSICOCHEMICAL CHARACTERIZATION AND IN-VITRO DISSOLUTION STUDIES OF DIOSMIN-CYCLODEXTRIN INCLUSION COMPLEXES,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 13, no. 4, pp. 1115–1123, 2014, [Online]. Available: https://sid.ir/paper/288321/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops