PLASMA VITAMIN D STATUS AND ITS CORRELATION WITH RISK FACTORS OF THROMBOSIS, P-SELECTIN AND HS-CRP LEVEL IN PATIENTS WITH VENOUS THROMBOEMBOLISM, THE FIRST STUDY OF IRANIAN POPULATION

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ENTEZARI MALEKI TAHER; HAJHOSSEIN TALASAZ AZITA; SALARIFAR MOJTABA; HADJIBABAIE MOLOUK; JAVADI MOHAMMAD REZA; BOZORGI ALI; JENAB YASER; BOROUMAND MOHAMMAD ALI; GHOLAMI KHEIROLLAH

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Journal: Iranian Journal of Pharmaceutical Research Year:2014 | Volume:13 | Issue:1 Page(s): 319-327

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Title

PLASMA VITAMIN D STATUS AND ITS CORRELATION WITH RISK FACTORS OF THROMBOSIS, P-SELECTIN AND HS-CRP LEVEL IN PATIENTS WITH VENOUS THROMBOEMBOLISM, THE FIRST STUDY OF IRANIAN POPULATION

Author(s)

Keywords

VITAMIN D DEFICIENCY

DVT

VTE

P-SELECTIN

HS-CRP

THROMBOSIS RISK FACTORS

Abstract

Low plasma level of vitamin D is linked to the increased risk of cardiovascular diseases such as hypertension, diabetes, dyslipidemia and PEripheral vascular diseases. VITAMIN D DEFICIENCY is a worldwide problem that involves Iranian population. To the best of our knowledge, this was the first investigation on venous thromboembolism (VTE) subjects that assessed the correlation of vitamin D level with plasma P-SELECTIN, HS-CRP, and risk factors of thrombosis.In this prospective pilot study, patients with diagnosis of acute deep vein thrombosis and/ or pulmonary embolism were enrolled. All patients’ clinical data, demographics and risk factors of thrombosis were evaluated. Plasma level of P-SELECTIN and HS-CRP were measured by ELISA method. Radio immune assay method was used to determine plasma level of 25-hydroxy vitamin D (25 (OH) D). In this study, 60 subjects were included. The mean±SD plasma 25-hydroxy vitamin D level (25 (OH) D) of participants was 21.4±14.6 ng/mL. The VITAMIN D DEFICIENCY was detected in 60% of patients. No significant relation was found between the plasma 25 (OH) D level and P-SELECTIN and HS-CRP. In multiple regression analysis, there was a significant relationship between the level of 25 (OH) D and the patients’ age (beta=0.452; p=0.001), diabetes (beta=0.280; p=0.036) and positive family history of cardiovascular diseases (beta=0.373; p=0.003).VITAMIN D DEFICIENCY is a frequent problem in Iranian VTE patients. Moreover, Plasma level of vitamin D is not associated with P-SELECTIN and HS-CRP in VTE patients.

Cites

ROLE OF VITAMIN D IN CARDIOVASCULAR DISEASE

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APA: Copy

ENTEZARI MALEKI, TAHER, HAJHOSSEIN TALASAZ, AZITA, SALARIFAR, MOJTABA, HADJIBABAIE, MOLOUK, JAVADI, MOHAMMAD REZA, BOZORGI, ALI, JENAB, YASER, BOROUMAND, MOHAMMAD ALI, & GHOLAMI, KHEIROLLAH. (2014). PLASMA VITAMIN D STATUS AND ITS CORRELATION WITH RISK FACTORS OF THROMBOSIS, P-SELECTIN AND HS-CRP LEVEL IN PATIENTS WITH VENOUS THROMBOEMBOLISM, THE FIRST STUDY OF IRANIAN POPULATION. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(1), 319-327. SID. https://sid.ir/paper/288334/en

Vancouver: Copy

ENTEZARI MALEKI TAHER, HAJHOSSEIN TALASAZ AZITA, SALARIFAR MOJTABA, HADJIBABAIE MOLOUK, JAVADI MOHAMMAD REZA, BOZORGI ALI, JENAB YASER, BOROUMAND MOHAMMAD ALI, GHOLAMI KHEIROLLAH. PLASMA VITAMIN D STATUS AND ITS CORRELATION WITH RISK FACTORS OF THROMBOSIS, P-SELECTIN AND HS-CRP LEVEL IN PATIENTS WITH VENOUS THROMBOEMBOLISM, THE FIRST STUDY OF IRANIAN POPULATION. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2014;13(1):319-327. Available from: https://sid.ir/paper/288334/en

IEEE: Copy

TAHER ENTEZARI MALEKI, AZITA HAJHOSSEIN TALASAZ, MOJTABA SALARIFAR, MOLOUK HADJIBABAIE, MOHAMMAD REZA JAVADI, ALI BOZORGI, YASER JENAB, MOHAMMAD ALI BOROUMAND, and KHEIROLLAH GHOLAMI, “PLASMA VITAMIN D STATUS AND ITS CORRELATION WITH RISK FACTORS OF THROMBOSIS, P-SELECTIN AND HS-CRP LEVEL IN PATIENTS WITH VENOUS THROMBOEMBOLISM, THE FIRST STUDY OF IRANIAN POPULATION,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 13, no. 1, pp. 319–327, 2014, [Online]. Available: https://sid.ir/paper/288334/en

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