SOLID LIPID NANOPARTICLES OF ATOVAQUONE BASED ON 24 FULL-FACTORIAL DESIGN

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MOHTAR NORATIQAH; K. KHAN NURZALINA A.; DARWIS YUSRIDA

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Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2015 | Volume:14 | Issue:4 Page(s): 989-1000

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Information Journal Paper

Title

SOLID LIPID NANOPARTICLES OF ATOVAQUONE BASED ON 24 FULL-FACTORIAL DESIGN

Author(s)

MOHTAR NORATIQAH | K. KHAN NURZALINA A. | DARWIS YUSRIDA | Issue Writer Certificate

Keywords

SOLID LIPID NANOPARTICLES

FACTORIAL DESIGN

ATOVAQUONE

TRIGLYCERIDES

SOY LECITHIN

Abstract

SOLID LIPID NANOPARTICLES of ATOVAQUONE (ATQ-SLN) were prepared by high shear homogenization method using tripalmitin, trilaurin, and Compritol 888 ATO as the lipid matrices and Phospholipon 90H, Tween 80, and poloxamer 188 as the surfactants. Optimization of the formulations was conducted using 6 sets of 24 full-factorial design based on four independent variables that were the number of homogenizing cycles, concentration of the lipid, concentration of the co-surfactant, and concentration of the main surfactant. The dependent variables were particle size and polydispersity index (PdI). The homogenizing cycles showed a negative influence on the dependent variables which reduced both the particle size and the PdI value. Moreover, a combination of certain percentages of the main surfactant and co-surfactant also showed a negative influence that reduced both the particle size and PdI value. Selected formulations from each design were further characterized for the entrapment efficiency and yield. The optimised formulation of ATQ-SLN consisted of trilaurin, Phospholipon 90H and Tween 80 with a particle size of 89.4 ± 0.2 nm and entrapment efficiency of 83.0 ± 1.7%. The in-vitro release evaluation of the formulation showed a complete and immediate release of ATQ from the SLN that could be a solution to improve the poor aqueous solubility and hence poor bioavailability of the drug.

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APA: Copy

MOHTAR, NORATIQAH, K. KHAN, NURZALINA A., & DARWIS, YUSRIDA. (2015). SOLID LIPID NANOPARTICLES OF ATOVAQUONE BASED ON 2⁴ FULL-FACTORIAL DESIGN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 14(4), 989-1000. SID. https://sid.ir/paper/288374/en

Vancouver: Copy

MOHTAR NORATIQAH, K. KHAN NURZALINA A., DARWIS YUSRIDA. SOLID LIPID NANOPARTICLES OF ATOVAQUONE BASED ON 2⁴ FULL-FACTORIAL DESIGN. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2015;14(4):989-1000. Available from: https://sid.ir/paper/288374/en

IEEE: Copy

NORATIQAH MOHTAR, NURZALINA A. K. KHAN, and YUSRIDA DARWIS, “SOLID LIPID NANOPARTICLES OF ATOVAQUONE BASED ON 2⁴ FULL-FACTORIAL DESIGN,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 14, no. 4, pp. 989–1000, 2015, [Online]. Available: https://sid.ir/paper/288374/en

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