ELECTROCHEMICAL SYNTHESIS AND KINETIC EVALUATION OF ELECTRO OXIDATION OF ACETAMINOPHEN IN THE PRESENCE OF ANTIDEPRESSANT DRUGS

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NEMATOLLAHI DAVOOD; FEYZI BARNAJI BAHAREH; AMANI AMENEH

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Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2015 | Volume:14 | Issue:4 Page(s): 1115-1122

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Information Journal Paper

Title

ELECTROCHEMICAL SYNTHESIS AND KINETIC EVALUATION OF ELECTRO OXIDATION OF ACETAMINOPHEN IN THE PRESENCE OF ANTIDEPRESSANT DRUGS

Author(s)

NEMATOLLAHI DAVOOD | FEYZI BARNAJI BAHAREH | AMANI AMENEH | Issue Writer Certificate

Keywords

ACETAMINOPHEN

PARACETAMOL

ANTIDEPRESSANT DRUGS

DRUG-DRUG INTERACTION

CYCLIC VOLTAMMETRIC

Abstract

h the aim of obtaining information about DRUG-DRUG INTERACTION (DDI) between ACETAMINOPHEN and some of ANTIDEPRESSANT DRUGS (fluoxetine, sertraline and nortriptyline), in the present work we studied the electrochemical oxidation of ACETAMINOPHEN (paracetamol) in the presence of these drugs by means of cyclic voltammetry and Controlled-potential coulometry. The reaction between N-acetyl-p-benzoquinone-imine (NAPQI) produced from electro oxidation of ACETAMINOPHEN and ANTIDEPRESSANT DRUGS (see scheme 1) cause to reduce the concentration of NAPQI and decreases the effective concentration of antidepressants. The CYCLIC VOLTAMMETRIC data were analyzed by digital simulation to measure the homogeneous parameters for the suggesting electrode mechanism. The calculated observed homogeneous rate constants (kobs) for the reaction of electrochemically generated N-acetyl-para benzoquinn-imine with ANTIDEPRESSANT DRUGS was found to vary in the order kobsnortriptyline > kobssertraline > kobsfluoxetine at biological pH.

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APA: Copy

NEMATOLLAHI, DAVOOD, FEYZI BARNAJI, BAHAREH, & AMANI, AMENEH. (2015). ELECTROCHEMICAL SYNTHESIS AND KINETIC EVALUATION OF ELECTRO OXIDATION OF ACETAMINOPHEN IN THE PRESENCE OF ANTIDEPRESSANT DRUGS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 14(4), 1115-1122. SID. https://sid.ir/paper/288377/en

Vancouver: Copy

NEMATOLLAHI DAVOOD, FEYZI BARNAJI BAHAREH, AMANI AMENEH. ELECTROCHEMICAL SYNTHESIS AND KINETIC EVALUATION OF ELECTRO OXIDATION OF ACETAMINOPHEN IN THE PRESENCE OF ANTIDEPRESSANT DRUGS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2015;14(4):1115-1122. Available from: https://sid.ir/paper/288377/en

IEEE: Copy

DAVOOD NEMATOLLAHI, BAHAREH FEYZI BARNAJI, and AMENEH AMANI, “ELECTROCHEMICAL SYNTHESIS AND KINETIC EVALUATION OF ELECTRO OXIDATION OF ACETAMINOPHEN IN THE PRESENCE OF ANTIDEPRESSANT DRUGS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 14, no. 4, pp. 1115–1122, 2015, [Online]. Available: https://sid.ir/paper/288377/en

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