THE EFFICACY OF 100 AND 300 MG GABAPENTIN IN THE TREATMENT OF CARPAL TUNNEL SYNDROME

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EFTEKHARSADAT BINA; BABAEI GHAZANI ARASH; HABIBZADEH AFSHIN

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Journal: Iranian Journal of Pharmaceutical Research Year:2015 | Volume:14 | Issue:4 Page(s): 1275-1280

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Title

THE EFFICACY OF 100 AND 300 MG GABAPENTIN IN THE TREATMENT OF CARPAL TUNNEL SYNDROME

Author(s)

EFTEKHARSADAT BINA | BABAEI GHAZANI ARASH | HABIBZADEH AFSHIN | Issue Writer Certificate

Keywords

GABAPENTIN

CARPAL TUNNEL SYNDROME

BCTQ

VAS

Abstract

Carpal tunnel syndrome (CTS) is a neuropathy due to the compression of the median nerve. It is shown that GABAPENTIN in high doses is effective in treatment of CTS patients. In this study we evaluated the efficacy of low doses of GABAPENTIN in treatment of CTS patients. Ninety patients with CTS were randomly assigned to groups A, B and C. GABAPENTIN was administered to group A with dose of 100 mg/day and to group B with dose of 300 mg/day for 2 months. Group C received no treatment. Before and after treatment, patients were evaluated using Visual analogue scale (VAS) for pain and parasthesia, Boston carpal tunnel questionnaire (BCTQ) including Symptom Severity Scale (SSS) and Functional Status Scale (FSS) to evaluate the efficacy of the treatment. The pinch and grip strength was also measured. There was significant improvement in VAS, grip strength, pinch strength, SSS, FSS and BCTQ score in all three groups (p < 0.05), but the changes in CMAP and SNAP was not significant. Groups A and B in comparison to group C had significantly better improvement in VAS, pinch strength, SSS, FSS and BCTQ total score (p < 0.05). There was significantly more improvement in pinch strength and SSS score in group B compared to group A (p < 0.05). GABAPENTIN in low doses is a useful drug in treatment of CTS symptoms with no side effects and intolerance. GABAPENTIN with dose of 300 mg/day is more effective than the dose of 100 mg/day.

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APA: Copy

EFTEKHARSADAT, BINA, BABAEI GHAZANI, ARASH, & HABIBZADEH, AFSHIN. (2015). THE EFFICACY OF 100 AND 300 MG GABAPENTIN IN THE TREATMENT OF CARPAL TUNNEL SYNDROME. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 14(4), 1275-1280. SID. https://sid.ir/paper/288383/en

Vancouver: Copy

EFTEKHARSADAT BINA, BABAEI GHAZANI ARASH, HABIBZADEH AFSHIN. THE EFFICACY OF 100 AND 300 MG GABAPENTIN IN THE TREATMENT OF CARPAL TUNNEL SYNDROME. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2015;14(4):1275-1280. Available from: https://sid.ir/paper/288383/en

IEEE: Copy

BINA EFTEKHARSADAT, ARASH BABAEI GHAZANI, and AFSHIN HABIBZADEH, “THE EFFICACY OF 100 AND 300 MG GABAPENTIN IN THE TREATMENT OF CARPAL TUNNEL SYNDROME,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 14, no. 4, pp. 1275–1280, 2015, [Online]. Available: https://sid.ir/paper/288383/en

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