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Information Journal Paper

Title

ANTIULCER PROPERTIES OF GLYCYRRHIZA GLABRA L. EXTRACT ON EXPERIMENTAL MODELS OF GASTRIC ULCER IN MICE

Pages

  1163-1170

Abstract

 Glycyrrhiza glabra L. is used in folk medicine for treatment of stomach disorders including PEPTIC ULCERs. The hydro alcoholic extract of GLYCYRRHIZA GLABRA L. (HEGG) was evaluated for antiulcero genic activity and acute toxicity profile in mice. Various doses of HEGG (50-200 mg/kg) were administered orally to animals of different groups. Omeprazole and cimetidine at doses of 30 and 100 mg/kg were used as positive controls, respectively. Stomach was opened along the greater curvature then ulceration index was determined examining the inner lining of stomach.Oral administration of the extract at 1600 mg/kg did not produce toxic symptoms and mortality in mice. 2950 mg/kg was determined as the oral LD50. The HEGG (50–200 mg/kg) showed a significant reduction in ulcer index in HCl/Ethanol-induced ulcer. G. glabra extract (50-150 mg/kg) showed antiulcer activity against INDOMETHACIN-induced gastric lesions dose dependently. The extract effectively inhibited formation of gastric lesions induced by ETHANOL. The extract (200 mg/kg) was more potent than omeprazole (30 mg/kg). HEGG reduced the ulcer index in hypothermic STRESS induced gastric ulcers in mice and the antiulcer effect was comparable to that of cimetidine.The results indicated that G. glabra hydro alcoholic extract exerted an antiulcer genic effect that could be associated with increase in gastric mucosal defensive factors.

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    Cite

    APA: Copy

    JALILZADEH AMINA, GHADER, NAJARNEZHAD, VAHID, ANASSORI, EHSAN, MOSTAFAVI, MOSTAFA, & KESHIPOUR, HADI. (2015). ANTIULCER PROPERTIES OF GLYCYRRHIZA GLABRA L. EXTRACT ON EXPERIMENTAL MODELS OF GASTRIC ULCER IN MICE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 14(4), 1163-1170. SID. https://sid.ir/paper/288400/en

    Vancouver: Copy

    JALILZADEH AMINA GHADER, NAJARNEZHAD VAHID, ANASSORI EHSAN, MOSTAFAVI MOSTAFA, KESHIPOUR HADI. ANTIULCER PROPERTIES OF GLYCYRRHIZA GLABRA L. EXTRACT ON EXPERIMENTAL MODELS OF GASTRIC ULCER IN MICE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2015;14(4):1163-1170. Available from: https://sid.ir/paper/288400/en

    IEEE: Copy

    GHADER JALILZADEH AMINA, VAHID NAJARNEZHAD, EHSAN ANASSORI, MOSTAFA MOSTAFAVI, and HADI KESHIPOUR, “ANTIULCER PROPERTIES OF GLYCYRRHIZA GLABRA L. EXTRACT ON EXPERIMENTAL MODELS OF GASTRIC ULCER IN MICE,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 14, no. 4, pp. 1163–1170, 2015, [Online]. Available: https://sid.ir/paper/288400/en

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