مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

SCREENING OF 20 COMMONLY USED IRANIAN TRADITIONAL MEDICINAL PLANTS AGAINST UREASE

Pages

  195-198

Abstract

 Infection with Helicobacter pyloriis the most common cause of stomach and duodenal ulcers. About more than 80 % of people are infected with H. PYLORI in developing countries. H. PYLORI uses UREASE enzyme product "ammonia" in order to neutralize and protect itself from the stomach acidic condition and UREASE enzyme activity has been shown to be essential to the colonization of H. PYLORI. Inhibitory activity of 20 traditional medicinal plants were examined and evaluated against Jack bean UREASE activity by Berthelot reaction to obtains natural sources of UREASE inhibitors. Each herb was extracted using 80% aqueous methanol, then tested its IC50 value was determined. Eight of the whole 20 studied plants crude EXTRACTS were found the most effective with IC50 values of less than 100 mg/mL including Laurus nobilis, Zingiber officinale, Nigella sativa, Angelica archangelica, Acorus calamus, Allium sativum, Curcuma longa, and Citrus aurantium EXTRACTS, from which most potent UREASE inhibitory was observed for Zingiber officinale, Laurus nobilis, and Nigella sativa with IC50 values of 48.54, 48.69 and 59.10 mg/mL, respectively.

Cites

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  • Cite

    APA: Copy

    BIGLAR, MAHMOOD, SUFI, HESSAMEDDIN, BAGHERZADEH, KOWSAR, AMANLOU, MASSOUD, & MOJAB, FARAZ. (2014). SCREENING OF 20 COMMONLY USED IRANIAN TRADITIONAL MEDICINAL PLANTS AGAINST UREASE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(SUPPL), 195-198. SID. https://sid.ir/paper/288412/en

    Vancouver: Copy

    BIGLAR MAHMOOD, SUFI HESSAMEDDIN, BAGHERZADEH KOWSAR, AMANLOU MASSOUD, MOJAB FARAZ. SCREENING OF 20 COMMONLY USED IRANIAN TRADITIONAL MEDICINAL PLANTS AGAINST UREASE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2014;13(SUPPL):195-198. Available from: https://sid.ir/paper/288412/en

    IEEE: Copy

    MAHMOOD BIGLAR, HESSAMEDDIN SUFI, KOWSAR BAGHERZADEH, MASSOUD AMANLOU, and FARAZ MOJAB, “SCREENING OF 20 COMMONLY USED IRANIAN TRADITIONAL MEDICINAL PLANTS AGAINST UREASE,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 13, no. SUPPL, pp. 195–198, 2014, [Online]. Available: https://sid.ir/paper/288412/en

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