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Information Journal Paper

Title

THE EFFECT OF GARCIN® IN PREVENTING ANTITB-INDUCED HEPATITIS IN NEWLY DIAGNOSED TUBERCULOSIS PATIENTS

Pages

  169-175

Abstract

 Adverse effects of antituberculosis agents such as hepatotoxicity may reduce treatment effectiveness, because they significantly contribute to nonadherence and eventually result in treatment failure, relapse or the emergence of drug resistance. GARLIC is an ancient herbal substance, which its effectiveness on isoniazid and rifampicin-induced hepatic injury in animal models has been demonstrated (1).In the present study a randomized, double blind, placebo-controlled, parallel group CLINICAL TRIAL was designed to assess the effect (s) of GARLIC tablets (1000 mg daily) administered for two weeks orally. Fifty eight newly diagnosed, smear positive pulmonary TUBERCULOSIS patients, with age ranges between 18-65 years old, were randomly allocated into two groups. Each patient received either GARLIC or placebo tablets for the first two weeks of TUBERCULOSIS treatment.Of total 58 patients, 31 received GARLIC tablets while 27 received placebo. No significant difference was found between the two groups regarding age, sex, nationality, smoking, underlying diseases and opium usage. During 8 weeks of anti-TB (antituberculosis) treatment, 8 (13.0%) patients developed drug-induced hepatotoxicity (DIH). Of them, 6 (75%) occurred in the first two weeks of treatment. Fifty percent of the patients who developed DIH were in GARLIC group. Results indicated no significant difference between groups in developing DIH (p=1.000).We could not show a significant role in preventing DIH by 1000 mg daily GARLIC administration.

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    APA: Copy

    TABARSI, PAYAM, FAHIMI, FANAK, HEIDARZADEH, NADER, HAGHGOO, ROODABEH, KAZEMPOUR, MEHDI, MASJEDI, MOHAMMADREZA, & VELAYATI, ALI AKBAR. (2014). THE EFFECT OF GARCIN® IN PREVENTING ANTITB-INDUCED HEPATITIS IN NEWLY DIAGNOSED TUBERCULOSIS PATIENTS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(SUPPL), 169-175. SID. https://sid.ir/paper/288423/en

    Vancouver: Copy

    TABARSI PAYAM, FAHIMI FANAK, HEIDARZADEH NADER, HAGHGOO ROODABEH, KAZEMPOUR MEHDI, MASJEDI MOHAMMADREZA, VELAYATI ALI AKBAR. THE EFFECT OF GARCIN® IN PREVENTING ANTITB-INDUCED HEPATITIS IN NEWLY DIAGNOSED TUBERCULOSIS PATIENTS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2014;13(SUPPL):169-175. Available from: https://sid.ir/paper/288423/en

    IEEE: Copy

    PAYAM TABARSI, FANAK FAHIMI, NADER HEIDARZADEH, ROODABEH HAGHGOO, MEHDI KAZEMPOUR, MOHAMMADREZA MASJEDI, and ALI AKBAR VELAYATI, “THE EFFECT OF GARCIN® IN PREVENTING ANTITB-INDUCED HEPATITIS IN NEWLY DIAGNOSED TUBERCULOSIS PATIENTS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 13, no. SUPPL, pp. 169–175, 2014, [Online]. Available: https://sid.ir/paper/288423/en

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