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Information Journal Paper

Title

NATURAL COMPOUNDS TARGET MITOCHONDRIAL ALTERATIONS IN CANCER CELL: NEW AVENUE FOR ANTICANCER RESEARCH (EDITORIAL)

Pages

  1-2

Keywords

Not Registered.

Abstract

 Mitochondria are semi-autonomous organelles that play essential roles in cellular metabolism and programmed cell death pathways. Functional, structural and genomic alterations in mitochondria have been associated with carcinogenesis in different cells. Some of those alterations may provide a selective advantage to cells, allowing them to survive and grow under different stresses. Due to the specific alterations that occur in cancer cell mitochondria, these organelles may provide promising targets for cancer therapy. The development of drugs that specifically target metabolic and mitochondrial alterations in tumor cells has become a matter of interest in recent years, with several molecules undergoing clinical trials. This Editorial focuses on the most relevant mitochondrial alterations found in tumor cells, for cancer therapy.Since transformed cells have metabolic and mitochondrial needs that differ from their normal counterparts, mitochondrial alterations in cancer cells can offer a window of opportunity for efficient and selective anti-cancer therapy. This principle of oncogenic alterations is in fact the basis for new anticancer research and can also be used with success when targeting altered aspects of tumor cell mitochondria. All the previous published works in this regard suggest that there is no mitochondrial alteration common to all cancer types, which excludes the use of a single mitochondrial-acting agent for all cancers. There are candidate natural compounds, in different stages of drug development, which have been described to interfere with mitochondrial functions in tumor cells, leading to cell cycle arrest and/or death by apoptosis or necrosis.

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    APA: Copy

    POURAHMAD, JALAL, SALIMI, AHMAD, & SEYDI, ENAYATOLLAH. (2014). NATURAL COMPOUNDS TARGET MITOCHONDRIAL ALTERATIONS IN CANCER CELL: NEW AVENUE FOR ANTICANCER RESEARCH (EDITORIAL). IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(SUPPL), 1-2. SID. https://sid.ir/paper/288424/en

    Vancouver: Copy

    POURAHMAD JALAL, SALIMI AHMAD, SEYDI ENAYATOLLAH. NATURAL COMPOUNDS TARGET MITOCHONDRIAL ALTERATIONS IN CANCER CELL: NEW AVENUE FOR ANTICANCER RESEARCH (EDITORIAL). IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2014;13(SUPPL):1-2. Available from: https://sid.ir/paper/288424/en

    IEEE: Copy

    JALAL POURAHMAD, AHMAD SALIMI, and ENAYATOLLAH SEYDI, “NATURAL COMPOUNDS TARGET MITOCHONDRIAL ALTERATIONS IN CANCER CELL: NEW AVENUE FOR ANTICANCER RESEARCH (EDITORIAL),” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 13, no. SUPPL, pp. 1–2, 2014, [Online]. Available: https://sid.ir/paper/288424/en

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