THE EFFECT OF AMLODIPINE AND SILDENAFIL ON THE NT-PROBNP LEVEL OF PATIENTS WITH COPD-INDUCED PULMONARY HYPERTENSION

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SHARIF KASHANI BABAK; HAMRAGHANI ALI; SALAMZADEH JAMSHID; ABBASI NAZAR MOHAMMAD; MALEKMOHAMMAD MAJID; BEHZADNIA NEDA; FAHIMI FANAK

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Journal: Iranian Journal of Pharmaceutical Research Year:2014 | Volume:13 | Issue:SUPPL Page(s): 161-168

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Title

THE EFFECT OF AMLODIPINE AND SILDENAFIL ON THE NT-PROBNP LEVEL OF PATIENTS WITH COPD-INDUCED PULMONARY HYPERTENSION

Author(s)

Keywords

PULMONARY HYPERTENSION

CHRONIC OBSTRUCTIVE PULMONARY DISEASE

NT-PROBNP

AMLODIPINE

SILDENAFIL

Abstract

PULMONARY HYPERTENSION (PH) is an important cause of heart failure in CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD). The pro brain natriuretic peptide N-terminal (NT-proBNP) has been suggested as a noninvasive marker to evaluate ventricular function. However, there is no evidence to support the use of NT-PROBNP in monitoring the benefits of vasodilators in COPD induced PH. Thus, we used NT-PROBNP as a biomarker to evaluate the effect of oral vasodilators on cardiac function in COPD-induced PH.Forty clinically-stable PH patients were enrolled with history of COPD, normal left ventricular ejection-fraction (LVEF), right ventricular systolic pressure (RVSP)>45 mmHg and baseline blood NT-PROBNP levels>100 pg/mL. Patients were randomized into two groups, one group received SILDENAFIL and second group were given AMLODIPINE for two weeks. NT- proBNP and systolic pulmonary arterial pressure (systolic PA-pressure) were measured at the beginning and the end of study.Mean NT-PROBNP level in the first group was 1297±912 pg/mL before therapy and 554±5 pg/mL after two weeks drug therapy, respectively. Similarly, in second group NT- proBNP level was 1657±989 pg/mL and 646±5 pg/mL before and after treatment. AMLODIPINE or SILDENAFIL significantly reduced NT-PROBNP levels in COPD-induced PH patients (p<0.05). Our study shows that AMLODIPINE and SILDENAFIL have a similar effect on NT-PROBNP levels. In both groups NT- proBNP levels were significantly reduced after treatment. Therefore, our findings support the potential benefits of treatment with vasodilators in COPD induced PH.

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APA: Copy

SHARIF KASHANI, BABAK, HAMRAGHANI, ALI, SALAMZADEH, JAMSHID, ABBASI NAZAR, MOHAMMAD, MALEKMOHAMMAD, MAJID, BEHZADNIA, NEDA, & FAHIMI, FANAK. (2014). THE EFFECT OF AMLODIPINE AND SILDENAFIL ON THE NT-PROBNP LEVEL OF PATIENTS WITH COPD-INDUCED PULMONARY HYPERTENSION. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 13(SUPPL), 161-168. SID. https://sid.ir/paper/288433/en

Vancouver: Copy

SHARIF KASHANI BABAK, HAMRAGHANI ALI, SALAMZADEH JAMSHID, ABBASI NAZAR MOHAMMAD, MALEKMOHAMMAD MAJID, BEHZADNIA NEDA, FAHIMI FANAK. THE EFFECT OF AMLODIPINE AND SILDENAFIL ON THE NT-PROBNP LEVEL OF PATIENTS WITH COPD-INDUCED PULMONARY HYPERTENSION. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2014;13(SUPPL):161-168. Available from: https://sid.ir/paper/288433/en

IEEE: Copy

BABAK SHARIF KASHANI, ALI HAMRAGHANI, JAMSHID SALAMZADEH, MOHAMMAD ABBASI NAZAR, MAJID MALEKMOHAMMAD, NEDA BEHZADNIA, and FANAK FAHIMI, “THE EFFECT OF AMLODIPINE AND SILDENAFIL ON THE NT-PROBNP LEVEL OF PATIENTS WITH COPD-INDUCED PULMONARY HYPERTENSION,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 13, no. SUPPL, pp. 161–168, 2014, [Online]. Available: https://sid.ir/paper/288433/en

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