مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

192
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

90
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

The Protective Effect of Sodium Ferulate and Oxymatrine Combination on Paraquat-induced Lung Injury

Pages

  573-583

Abstract

 Experimental evidence suggested that Sodium ferulate (SF) and Oxymatrine (OMT) combination had synergistic anti-inflammatory and antioxidant effects. We hypothesized that SF and OMT combination treatment might have protective effects on Paraquat-induced acute Lung injury. In our study, the Swiss mice were randomly divided into seven groups, including control, Paraquat (PQ), SF (6. 2 mg/Kg/day); OMT (13. 8 mg/Kg/day) and three SF+OMT groups (3. 1 + 6. 9; 6. 2 + 13. 8 and 12. 3 + 27. 7 mg/Kg/day). The mortality and death time were monitored. Sprague-Dawley rats were randomly divided into seven groups including control, PQ, SF (3. 1 mg/Kg/day); OMT (6. 9 mg/Kg/day) and three SF+OMT groups (1. 6 + 3. 4; 3. 1 + 6. 9 and 6. 2 + 13. 8 mg/Kg/day). The Lung wet/dry weight (W/D) ratio, Lung histopathologic changes, C-reactive protein (CRP), interleukin-6 (IL-6), nuclear factor κ B (NF-κ B), malondialdehyde (MDA) and superoxidase dismutase (SOD) were analysed. Compared with PQ group, the mortality significantly decreased and the death time prolonged in SF and OMT combination treatment groups of mice. Also in SF and OMT combination treatment groups of rats, the increased Lung W/D ratio and histopathological score induced by PQ injection were significantly decreased; the levels of CRP, IL-6, NF-κ B and MDA in serum and Lung homogenate were significantly decreased; the SOD activities in serum and Lung homogenate were improved. These results suggested that SF and OMT combination had an obvious protective effect on PQ-induced Lung injury. The anti-infl ammatory and antioxidant effect might be involved in the mechanism.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    WANG, WEI, Pei, Xiaokun, Xu, Mengxin, Sun, Songmei, Zhang, Chunlei, Mu, Keying, & Liu, Zhifeng. (2015). The Protective Effect of Sodium Ferulate and Oxymatrine Combination on Paraquat-induced Lung Injury. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 14(2), 573-583. SID. https://sid.ir/paper/288450/en

    Vancouver: Copy

    WANG WEI, Pei Xiaokun, Xu Mengxin, Sun Songmei, Zhang Chunlei, Mu Keying, Liu Zhifeng. The Protective Effect of Sodium Ferulate and Oxymatrine Combination on Paraquat-induced Lung Injury. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2015;14(2):573-583. Available from: https://sid.ir/paper/288450/en

    IEEE: Copy

    WEI WANG, Xiaokun Pei, Mengxin Xu, Songmei Sun, Chunlei Zhang, Keying Mu, and Zhifeng Liu, “The Protective Effect of Sodium Ferulate and Oxymatrine Combination on Paraquat-induced Lung Injury,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 14, no. 2, pp. 573–583, 2015, [Online]. Available: https://sid.ir/paper/288450/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button