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Information Journal Paper

Title

Development of a Rapid Derivative Spectrophotometric Method for Simultaneous Determination of Acetaminophen, Diphenhydramine and Pseudoephedrine in Tablets

Pages

  435-442

Abstract

 A mixture of Acetaminophen, Diphenhydramine hydrochloride and Pseudoephedrine hydrochloride is used for the symptomatic treatment of common cold. In this study, a derivative spectrophotometric method based on zero-crossing technique was proposed for simultaneous determination of Acetaminophen, Diphenhydramine hydrochloride and Pseudoephedrine hydrochloride. Determination of these drugs was performed using the 1D value of Acetaminophen at 281. 5 nm, 2D value of Diphenhydramine hydrochloride at 226. 0 nm and 4D value of Pseudoephedrine hydrochloride at 218. 0 nm. The analysis method was linear over the range of 5-50, 0. 25-4, and 0. 5-5 μ g/mL for Acetaminophen, Diphenhydramine hydrochloride and Pseudoephedrine hydrochloride, respectively. The within-day and between-day CV and error values for all three compounds were within an acceptable range (CV<2. 2% and error<3%). The developed method was used for simultaneous determination of these drugs in pharmaceutical dosage forms and no interference from excipients was observed.

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    • Cite

    APA: Copy

    SOURI, EFFAT, Rahimi, Aghil, SHABANI RAVARI, NAZANIN, & BARAZANDEH TEHRANI, MALIHEH. (2015). Development of a Rapid Derivative Spectrophotometric Method for Simultaneous Determination of Acetaminophen, Diphenhydramine and Pseudoephedrine in Tablets. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 14(2), 435-442. SID. https://sid.ir/paper/288452/en

    Vancouver: Copy

    SOURI EFFAT, Rahimi Aghil, SHABANI RAVARI NAZANIN, BARAZANDEH TEHRANI MALIHEH. Development of a Rapid Derivative Spectrophotometric Method for Simultaneous Determination of Acetaminophen, Diphenhydramine and Pseudoephedrine in Tablets. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2015;14(2):435-442. Available from: https://sid.ir/paper/288452/en

    IEEE: Copy

    EFFAT SOURI, Aghil Rahimi, NAZANIN SHABANI RAVARI, and MALIHEH BARAZANDEH TEHRANI, “Development of a Rapid Derivative Spectrophotometric Method for Simultaneous Determination of Acetaminophen, Diphenhydramine and Pseudoephedrine in Tablets,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 14, no. 2, pp. 435–442, 2015, [Online]. Available: https://sid.ir/paper/288452/en

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