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Information Journal Paper

Title

In-vitro and In-vivo Evaluation of Silymarin Nanoliposomes against Isolated Methicillin-resistant Staphylococcus aureus

Pages

  627-633

Abstract

 Staphylococcus aureus is an opportunistic pathogen and remains a common cause of burn wound infections. Different studies have shown that entrapment of plant-derived compounds into liposomes could increase their anti-Staphylococcus aureus activity. Silymarin is the bioactive extract from the known plant Silybum marianum L. The objective of this study was to evaluate efficacy of Silymarin in free and nanoliposomal forms against isolated methicillinresistant Staphylococcus aureus (MRSA) strain. Silymarin-loaded Nanoliposomes were prepared by extrusion method. The minimum inhibitory concentrations (MICs) of Silymarin in free and nanoliposomal forms against MRSA were determined by broth dilution method. The Killing rate of free and nanoliposomal forms of Silymarin were analyzed. Ultimately, invivo therapeutic efficacy of Nanoliposomes in burned mice infected by isolated MRSA was examined. The MICs of free and nanoliposomal forms of Silymarin against isolated strain were 500 and 125 mg/L, respectively. The Killing rate of Silymarin-loaded Nanoliposomes was higher than those of free Silymarin. Topically treatment by Silymarin in free and nanoliposomal forms resulted in almost 20 and 100% survival rates, respectively. The results suggest that Silymarinloaded Nanoliposomes may provide a basis for future treatment of MRSA infections.

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    APA: Copy

    FAEZIZADEH, ZOHREH, GHARIB, AMIR, & Godarzee, Masoud. (2015). In-vitro and In-vivo Evaluation of Silymarin Nanoliposomes against Isolated Methicillin-resistant Staphylococcus aureus. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 14(2), 627-633. SID. https://sid.ir/paper/288456/en

    Vancouver: Copy

    FAEZIZADEH ZOHREH, GHARIB AMIR, Godarzee Masoud. In-vitro and In-vivo Evaluation of Silymarin Nanoliposomes against Isolated Methicillin-resistant Staphylococcus aureus. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2015;14(2):627-633. Available from: https://sid.ir/paper/288456/en

    IEEE: Copy

    ZOHREH FAEZIZADEH, AMIR GHARIB, and Masoud Godarzee, “In-vitro and In-vivo Evaluation of Silymarin Nanoliposomes against Isolated Methicillin-resistant Staphylococcus aureus,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 14, no. 2, pp. 627–633, 2015, [Online]. Available: https://sid.ir/paper/288456/en

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