Cyclodextrine Screening for the Chiral Separation of Carvedilol by Capillary Electrophoresis

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HANCU GABRIEL; CARJE ANCA; Iuga Ileana; Fulop Ibolya; Szabo Zoltan Istvan

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2015 | Volume:14 | Issue:2 Page(s): 425-433

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Title

Cyclodextrine Screening for the Chiral Separation of Carvedilol by Capillary Electrophoresis

Author(s)

Keywords

Carvedilol

Capillary electrophoresis

Chirality

Cyclodextrines

Enantiomer separation

Abstract

Carvedilol is administered as a racemic mixture of the R(+)-and S(-)-enantiomers, although it was demonstrated that the two enantiomers exhibit different pharmacological effects and stereoselective pharmacokinetics. The aim of this study was the evaluation of several native and derivatized Cyclodextrines as chiral selectors for the separation of Carvedilol enantiomers. Stereoselective interactions were observed with four Cyclodextrines (β-CD, hydroxypropyl-β-CD, randomly methylated β-CD and sulfobuthyl ether-β-CD). The effects of CD concentration, pH value and composition of the background electrolyte, capillary temperature, running voltage and injection parameters have been investigated. The method was validated for precision of peak-area response, linearity range and limits of detection and quantification. An efficient stereoselective capillary zone electrophoretic method was developed for the determination of Carvedilol enantiomers using a simple 25 mM phosphate buffer at a pH = 2. 5 and 10 mM β-CD as chiral selector, resulting in baseline separation of the two enantiomers with sharp peaks and relatively short analysis time. Highly satisfactory results were obtained from the analysis of Carvedilol from tablets, indicating that the method is suitable for routine analysis of Carvedilol in pharmaceutical products.

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APA: Copy

HANCU, GABRIEL, CARJE, ANCA, Iuga, Ileana, Fulop, Ibolya, & Szabo, Zoltan Istvan. (2015). Cyclodextrine Screening for the Chiral Separation of Carvedilol by Capillary Electrophoresis. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 14(2), 425-433. SID. https://sid.ir/paper/288458/en

Vancouver: Copy

HANCU GABRIEL, CARJE ANCA, Iuga Ileana, Fulop Ibolya, Szabo Zoltan Istvan. Cyclodextrine Screening for the Chiral Separation of Carvedilol by Capillary Electrophoresis. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2015;14(2):425-433. Available from: https://sid.ir/paper/288458/en

IEEE: Copy

GABRIEL HANCU, ANCA CARJE, Ileana Iuga, Ibolya Fulop, and Zoltan Istvan Szabo, “Cyclodextrine Screening for the Chiral Separation of Carvedilol by Capillary Electrophoresis,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 14, no. 2, pp. 425–433, 2015, [Online]. Available: https://sid.ir/paper/288458/en

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