PROTEOME ANALYSIS OF RAT HIPPOCAMPUS FOLLOWING MORPHINE-INDUCED AMNESIA AND STATE-DEPENDENT LEARNING

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JAFARINEJAD FARSANGI Saeideh; FARAZMAND ALI; REZAYOF AMENEH; Darbandi Niloufar

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2015 | Volume:14 | Issue:2 Page(s): 591-602

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Title

PROTEOME ANALYSIS OF RAT HIPPOCAMPUS FOLLOWING MORPHINE-INDUCED AMNESIA AND STATE-DEPENDENT LEARNING

Author(s)

JAFARINEJAD FARSANGI Saeideh | FARAZMAND ALI | REZAYOF AMENEH | Darbandi Niloufar | Issue Writer Certificate

Keywords

Morphine

Hippocampus

Passive avoidance learning

Protein expression

Proteomics

Abstract

Morphine’ s effects on learning and memory processes are well known to depend on synaptic plasticity in the Hippocampus. Whereas the role of the Hippocampus in Morphine-induced amnesia and state-dependent learning is established, the biochemical and molecular mechanisms underlying these processes are poorly understood. The present study intended to investigate whether administration of Morphine can change the expression level of rat hippocampal proteins during learning of a passive avoidance task. A step-through type passive avoidance task was used for the assessment of memory retention. To identify the complex pattern of Protein expression induced by Morphine, we compared rat hippocampal proteome either in Morphine-induced amnesia or in state-dependent learning by two-dimensional gel electerophoresis and combined mass spectrometry (MS and MS/MS). Post-training administration of Morphine decreased step-through latency. Pre-test administration of Morphine induced state-dependent retrieval of the memory acquired under post-training Morphine influence. In the Hippocampus, a total of 18 proteins were identified whose MASCOT (Modular Approach to Software Construction Operation and Test) scores were inside 95% confidence level. Of these, five hippocampal proteins altered in Morphine-induced amnesia and ten proteins were found to change in the Hippocampus of animals that had received post-training and pre-test Morphine. These proteins show known functions in cytoskeletal architecture, cell metabolism, neurotransmitter secretion and neuroprotection. The findings indicate that the effect of Morphine on memory formation in Passive avoidance learning has a morphological correlate on the hippocampal proteome level. In addition, our proteomic screen suggests that Morphine induces memory impairment and state-dependent learning through modulating neuronal plasticity.

Cites

EFFECT OF PENTYLENETETRAZOL ON MORPHINE STATE-DEPENDENT MEMORY IN RAT

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APA: Copy

JAFARINEJAD FARSANGI, Saeideh, FARAZMAND, ALI, REZAYOF, AMENEH, & Darbandi, Niloufar. (2015). PROTEOME ANALYSIS OF RAT HIPPOCAMPUS FOLLOWING MORPHINE-INDUCED AMNESIA AND STATE-DEPENDENT LEARNING. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 14(2), 591-602. SID. https://sid.ir/paper/288459/en

Vancouver: Copy

JAFARINEJAD FARSANGI Saeideh, FARAZMAND ALI, REZAYOF AMENEH, Darbandi Niloufar. PROTEOME ANALYSIS OF RAT HIPPOCAMPUS FOLLOWING MORPHINE-INDUCED AMNESIA AND STATE-DEPENDENT LEARNING. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2015;14(2):591-602. Available from: https://sid.ir/paper/288459/en

IEEE: Copy

Saeideh JAFARINEJAD FARSANGI, ALI FARAZMAND, AMENEH REZAYOF, and Niloufar Darbandi, “PROTEOME ANALYSIS OF RAT HIPPOCAMPUS FOLLOWING MORPHINE-INDUCED AMNESIA AND STATE-DEPENDENT LEARNING,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 14, no. 2, pp. 591–602, 2015, [Online]. Available: https://sid.ir/paper/288459/en

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