The Effect of Chronic Administration of Safranal on Systolic Blood Pressure in Rats

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IMENSHAHIDI MOHSEN; RAZAVI BIBI MARJAN; FAAL AYYOOB; GHOLAMPOOR ALI; Mousavi Seyed Mehran; HOSSEINZADEH HOSSEIN

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Journal: Iranian Journal of Pharmaceutical Research Year:2015 | Volume:14 | Issue:2 Page(s): 585-590

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Title

The Effect of Chronic Administration of Safranal on Systolic Blood Pressure in Rats

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Keywords

Crocus sativus

Saffron

Safranal

Systolic blood pressure

Tail cuff

Abstract

Safranal, the main component of Crocus sativus essential oil, exhibits different pharmacological activities. In this study, the effects of Safranal, on blood pressure of normotensive and desoxycorticosterone acetate (DOCA)-salt induced hypertensive rats in chronic administration were investigated. Three doses of Safranal (1, 2 and 4 mg/Kg/day) and spironolactone (50 mg/Kg/day) were administrated to the different groups of normotensive and hypertensive rats (at the end of 4 weeks treatment by DOCA-salt) for Five weeks. Then the effects of Safranal on mean Systolic blood pressure (MSBP) and heart rate (HR) were evaluated using Tail cuff method. The duration of effect of Safranal on SBP, was also evaluated. Our results indicated that chronic administration of Safranal could reduce the MSBP in DOCA salt treated rats in a dose dependent manner. Safranal did not decrease the MSBP in normotensive rats. The data also showed that antihypertensive effects of Safranal did not persist. In summary, our results showed that Safranal exhibits antihypertensive and normalizing effect on BP in chronic administration.

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APA: Copy

IMENSHAHIDI, MOHSEN, RAZAVI, BIBI MARJAN, FAAL, AYYOOB, GHOLAMPOOR, ALI, Mousavi, Seyed Mehran, & HOSSEINZADEH, HOSSEIN. (2015). The Effect of Chronic Administration of Safranal on Systolic Blood Pressure in Rats. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 14(2), 585-590. SID. https://sid.ir/paper/288463/en

Vancouver: Copy

IMENSHAHIDI MOHSEN, RAZAVI BIBI MARJAN, FAAL AYYOOB, GHOLAMPOOR ALI, Mousavi Seyed Mehran, HOSSEINZADEH HOSSEIN. The Effect of Chronic Administration of Safranal on Systolic Blood Pressure in Rats. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2015;14(2):585-590. Available from: https://sid.ir/paper/288463/en

IEEE: Copy

MOHSEN IMENSHAHIDI, BIBI MARJAN RAZAVI, AYYOOB FAAL, ALI GHOLAMPOOR, Seyed Mehran Mousavi, and HOSSEIN HOSSEINZADEH, “The Effect of Chronic Administration of Safranal on Systolic Blood Pressure in Rats,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 14, no. 2, pp. 585–590, 2015, [Online]. Available: https://sid.ir/paper/288463/en

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