The Effect of Curcumin on some of Traditional and Non-traditional Cardiovascular Risk Factors: A Pilot Randomized, Double-blind, Placebo-controlled Trial

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Mirzabeigi Parastoo; MOHAMMADPOUR AMIR HOOSHANG; SALARIFAR MOJTABA; GHOLAMI KHEIROLLAH; MOJTAHEDZADEH MOJTABA; JAVADI MOHAMMAD REZA

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Journal: Iranian Journal of Pharmaceutical Research Year:2015 | Volume:14 | Issue:2 Page(s): 479-486

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Title

The Effect of Curcumin on some of Traditional and Non-traditional Cardiovascular Risk Factors: A Pilot Randomized, Double-blind, Placebo-controlled Trial

Author(s)

Keywords

Curcumin

Coronary artery disease

Lipid profile

hs-CRP

Blood glucose

Abstract

Numerous interventional studies in clinical and preclinical setting stated that intake of Curcumin may provide protection against cardiovascular disease. The aim of this trial was investigation of Curcumin efficiency on some cardiovascular risk factors in patients with Coronary artery disease (CAD). A total of 33 patients with CAD who fulfilled inclusion and exclusion criteria were entered the study. Patients were randomly assigned to receive Curcumin or placebo, 500 mg capsules, four times daily for 8 weeks. Lipid profile, Blood glucose and high sensitive C-reactive protein (hs-CRP) levels were analyzed at baseline and two months after treatment. Serum levels of triglycerides (P=0. 01), LDL-cholesterol (P=0. 03) and VLDLcholesterol (P=0. 04) significantly decreased in the Curcumin group compared to baseline, without significant changes in total cholesterol, HDL-cholesterol, Blood glucose and hs-CRP levels. In all mentioned laboratory parameters, significant difference was not detected between Curcumin and placebo. Although Curcumin improved some of Lipid profile components, it did not show appreciable effect on inflammatory markers in patients with CAD. Therefore, more detailed assessment of metabolic effects or anti-inflammatory activities of Curcumin need to perform by extensive human study.

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APA: Copy

Mirzabeigi, Parastoo, MOHAMMADPOUR, AMIR HOOSHANG, SALARIFAR, MOJTABA, GHOLAMI, KHEIROLLAH, MOJTAHEDZADEH, MOJTABA, & JAVADI, MOHAMMAD REZA. (2015). The Effect of Curcumin on some of Traditional and Non-traditional Cardiovascular Risk Factors: A Pilot Randomized, Double-blind, Placebo-controlled Trial. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 14(2), 479-486. SID. https://sid.ir/paper/288469/en

Vancouver: Copy

Mirzabeigi Parastoo, MOHAMMADPOUR AMIR HOOSHANG, SALARIFAR MOJTABA, GHOLAMI KHEIROLLAH, MOJTAHEDZADEH MOJTABA, JAVADI MOHAMMAD REZA. The Effect of Curcumin on some of Traditional and Non-traditional Cardiovascular Risk Factors: A Pilot Randomized, Double-blind, Placebo-controlled Trial. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2015;14(2):479-486. Available from: https://sid.ir/paper/288469/en

IEEE: Copy

Parastoo Mirzabeigi, AMIR HOOSHANG MOHAMMADPOUR, MOJTABA SALARIFAR, KHEIROLLAH GHOLAMI, MOJTABA MOJTAHEDZADEH, and MOHAMMAD REZA JAVADI, “The Effect of Curcumin on some of Traditional and Non-traditional Cardiovascular Risk Factors: A Pilot Randomized, Double-blind, Placebo-controlled Trial,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 14, no. 2, pp. 479–486, 2015, [Online]. Available: https://sid.ir/paper/288469/en

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