Synthesis and Antibacterial Evaluation of (S, Z)-4-methyl-2-(4-oxo-5-((5-substituted phenylfuran-2-yl) methylene)-2-thioxothiazolidin-3-yl) Pentanoic Acids

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SONG MING XIA; Denga Xian Qing; WEI Zhi Yu; Zheng Chang Ji; Wu Yan; An Chang Shan; Piao Hu Ri

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Journal: Iranian Journal of Pharmaceutical Research Year:2015 | Volume:14 | Issue:1 Page(s): 89-96

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Title

Synthesis and Antibacterial Evaluation of (S, Z)-4-methyl-2-(4-oxo-5-((5-substituted phenylfuran-2-yl) methylene)-2-thioxothiazolidin-3-yl) Pentanoic Acids

Author(s)

Keywords

Furan

Pentanoic acid

Antibacterial activity

Cytotoxicity

MRSA

QRSA

Abstract

The microbial resistance has become a global hazard with the irrational use of antibiotics. Infection of drug-resistant bacteria seriously threatens human health. Currently, there is an urgent need for the development of novel antimicrobial agents with new mechanisms and lower levels of toxicity. In this paper, a series of (S, Z)-4-methyl-2-(4-oxo-5-((5-substitutedphenylFuran-2-yl) methylene)-2-thioxothiazolidin-3-yl)Pentanoic acids via a Knoevenagel condensation were synthesized and evaluated for their Antibacterial activity in-vitro. The synthesized compounds were characterized by IR, 1H NMR and MS. The antibacterial test in-vitro showed that all of the synthesized compounds had good Antibacterial activity against several Gram-positive bacteria (including multidrug-resistant clinical isolates) with minimum inhibitory concentration (MIC) values in the range of 2– 4 μ g/mL. Especially compounds 4c, 4d, 4e and 4f were the most potent, with MIC values of 2 μ g/mL against four multidrug-resistant Gram-positive bacterial strains.

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APA: Copy

SONG, MING XIA, Denga, Xian Qing, WEI, Zhi Yu, Zheng, Chang Ji, Wu, Yan, An, Chang Shan, & Piao, Hu Ri. (2015). Synthesis and Antibacterial Evaluation of (S, Z)-4-methyl-2-(4-oxo-5-((5-substituted phenylfuran-2-yl) methylene)-2-thioxothiazolidin-3-yl) Pentanoic Acids. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 14(1), 89-96. SID. https://sid.ir/paper/288501/en

Vancouver: Copy

SONG MING XIA, Denga Xian Qing, WEI Zhi Yu, Zheng Chang Ji, Wu Yan, An Chang Shan, Piao Hu Ri. Synthesis and Antibacterial Evaluation of (S, Z)-4-methyl-2-(4-oxo-5-((5-substituted phenylfuran-2-yl) methylene)-2-thioxothiazolidin-3-yl) Pentanoic Acids. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2015;14(1):89-96. Available from: https://sid.ir/paper/288501/en

IEEE: Copy

MING XIA SONG, Xian Qing Denga, Zhi Yu WEI, Chang Ji Zheng, Yan Wu, Chang Shan An, and Hu Ri Piao, “Synthesis and Antibacterial Evaluation of (S, Z)-4-methyl-2-(4-oxo-5-((5-substituted phenylfuran-2-yl) methylene)-2-thioxothiazolidin-3-yl) Pentanoic Acids,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 14, no. 1, pp. 89–96, 2015, [Online]. Available: https://sid.ir/paper/288501/en

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