Comparison of the Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on the Eradication of Helicobacter pylori Infection, Serum Inflammatory Factors and Total Antioxidant Capacity

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KHANDOUZI NAFISEH; SHIDFAR FARZAD; AGAH SHAHRAM; HOSSEINI AGHA FATEMEH; DEHNAD AFSANEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2015 | Volume:14 | Issue:1 Page(s): 149-157

Download Full-Text

View:

191

Download:

113

Cites:

Information Journal Paper

Title

Comparison of the Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on the Eradication of Helicobacter pylori Infection, Serum Inflammatory Factors and Total Antioxidant Capacity

Author(s)

Keywords

Helicobacter pylori

Eicosapentaenoic acid

Docosahexaenoic acid

Eradication

Inflammatory factors

Abstract

Helicobacter pylori infection, the most common chronic bacterial infection in the world, and an important cause of gastrointestinal disorders, may be involved in the pathogenesis of some extra-gastrointestinal disturbances, as well as an increase in blood levels of certain inflammatory markers. Anti-bacterial activity against Helicobacter pylori and antiinflammatory properties of omega-3 fatty acids have been studied in several research studies. The purpose of the present study was the comparison of the effects of Eicosapentaenoic acid and Docosahexaenoic acid supplementation on Helicobacter pylori Eradication, serum levels of some inflammatory markers and total antioxidant capacity. In a randomized, double-blind, placebo-controlled clinical trial, 97 Helicobacter pylori positive patients (64 patients in the two intervention groups and 33 in the control group), received 2 grams daily of Eicosapentaenoic acid, Docosahexaenoic acid or Medium Chain Triglyceride oil as placebo, along with conventional tetra-drug Helicobacter pylori Eradication regimen, for 12 weeks. Helicobacter pylori Eradication test and measurement of concentration of interleukine-6, interleukine-8, high-sensitivity C-reactive protein and total antioxidant capacity were performed after the intervention. There was no significant difference in Eradication rate of the infection, levels of interleukine-6 and total antioxidant capacity among the three groups, while the levels of interleukine-8 and high-sensitivity C-reactive protein were statistically different. Eicosapentaenoic acid or Docosahexaenoic acid supplementation had no significant differential impact on the Eradication of Helicobacter pylori infection, and serum levels of interleukine-6 and total antioxidant capacity. However, it had a desirable effect on the levels of interleukine-8 and high-sensitivity C-reactive protein in Helicobacter pylori positive patients.

Cites

No record.

References

No record.

Cite

APA: Copy

KHANDOUZI, NAFISEH, SHIDFAR, FARZAD, AGAH, SHAHRAM, HOSSEINI, AGHA FATEMEH, & DEHNAD, AFSANEH. (2015). Comparison of the Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on the Eradication of Helicobacter pylori Infection, Serum Inflammatory Factors and Total Antioxidant Capacity. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 14(1), 149-157. SID. https://sid.ir/paper/288507/en

Vancouver: Copy

KHANDOUZI NAFISEH, SHIDFAR FARZAD, AGAH SHAHRAM, HOSSEINI AGHA FATEMEH, DEHNAD AFSANEH. Comparison of the Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on the Eradication of Helicobacter pylori Infection, Serum Inflammatory Factors and Total Antioxidant Capacity. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2015;14(1):149-157. Available from: https://sid.ir/paper/288507/en

IEEE: Copy

NAFISEH KHANDOUZI, FARZAD SHIDFAR, SHAHRAM AGAH, AGHA FATEMEH HOSSEINI, and AFSANEH DEHNAD, “Comparison of the Effects of Eicosapentaenoic Acid and Docosahexaenoic Acid on the Eradication of Helicobacter pylori Infection, Serum Inflammatory Factors and Total Antioxidant Capacity,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 14, no. 1, pp. 149–157, 2015, [Online]. Available: https://sid.ir/paper/288507/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops