ANALYSIS OF THE ANTI PROLIFERATIVE EFFECTS OF CURCUMIN AND NANOCURCUMIN IN MDA-MB231 AS A BREAST CANCER CELL LINE

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Khosropanah Mohammad Hossein; DINARVAND AMIN; Nezhadhosseini Afsaneh; Haghighi Alireza; HASHEMI SIMA; Nirouzad Fereidon; Khatamsaz Sepideh; ENTEZARI MALIHEH; HASHEMI MEHRDAD; DEHGHANI HOSSEIN

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Journal: Iranian Journal of Pharmaceutical Research Year:2016 | Volume:15 | Issue:1 Page(s): 231-239

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Title

ANALYSIS OF THE ANTI PROLIFERATIVE EFFECTS OF CURCUMIN AND NANOCURCUMIN IN MDA-MB231 AS A BREAST CANCER CELL LINE

Author(s)

Keywords

Anticancer activity

Curcumin

Nanocurcumin

MTT assay

Human breast adenocarcinoma.

Abstract

Cancer is one of the main causes of mortality in the world which appears by the effect of enviromental physico-chemical mutagen and carcinogen agents. The identification of new cytotoxic drug with low sid effects on immune system has developed as important area in new studies of immunopharmacology. Curcumin is a natural polyphenol with anti-oxidative, antiinflammatory and anti-cancer properties. Its therapeutic potential is substantially hindered by the rather low water solubility and bioavailability, hence the need for suitable carriers. In this report we employed nanogel-based nanoparticle approach to improve upon its effectiveness. Myristic acid-chitosan (MA-chitosan) nanogels were prepared by the technique of selfassembly. Curcumin was loaded into the nanogels. The surface morphology of the prepared nanoparticles was determined using SEM and TEM. The other objective of this study was to examine the in vitro cytotoxic activity of cell death of Curcumin and nanoCurcumin on Human breast adenocarcinoma.cell line (MDA-MB231). Cytotoxicity and viability of Curcumin and nanoCurcumin were assessed by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) and dye exclusion assay. Transmission electron microscopy confirmed the particle diameter was between 150 to 200 nm. Proliferation of MDA-MB231 cells was significantly inhibited by Curcumin and nanoCurcumin in a concentration-dependent manner in defined times. There were significant differences in IC50 Curcumin and nanoCurcumin. Curcumin-loaded nanoparticles proved more effective compared to TQ solution. The high drug-targeting potential and efficiency demonstrates the significant role of the anticancer properties of Curcumin-loaded nanoparticles.

Cites

COMPARISON OF PROTECTIVE EFFECT OF TWO TYPES OF AEROBIC AND INTERMITTENT TRAINING ON BREAST CANCER BY TGFβ PROTEIN AND SMAD-3 GENE AND MMP2 IN FEMALE MICE

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APA: Copy

Khosropanah, Mohammad Hossein, DINARVAND, AMIN, Nezhadhosseini, Afsaneh, Haghighi, Alireza, HASHEMI, SIMA, Nirouzad, Fereidon, Khatamsaz, Sepideh, ENTEZARI, MALIHEH, HASHEMI, MEHRDAD, & DEHGHANI, HOSSEIN. (2016). ANALYSIS OF THE ANTI PROLIFERATIVE EFFECTS OF CURCUMIN AND NANOCURCUMIN IN MDA-MB231 AS A BREAST CANCER CELL LINE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 15(1), 231-239. SID. https://sid.ir/paper/288527/en

Vancouver: Copy

Khosropanah Mohammad Hossein, DINARVAND AMIN, Nezhadhosseini Afsaneh, Haghighi Alireza, HASHEMI SIMA, Nirouzad Fereidon, Khatamsaz Sepideh, ENTEZARI MALIHEH, HASHEMI MEHRDAD, DEHGHANI HOSSEIN. ANALYSIS OF THE ANTI PROLIFERATIVE EFFECTS OF CURCUMIN AND NANOCURCUMIN IN MDA-MB231 AS A BREAST CANCER CELL LINE. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2016;15(1):231-239. Available from: https://sid.ir/paper/288527/en

IEEE: Copy

Mohammad Hossein Khosropanah, AMIN DINARVAND, Afsaneh Nezhadhosseini, Alireza Haghighi, SIMA HASHEMI, Fereidon Nirouzad, Sepideh Khatamsaz, MALIHEH ENTEZARI, MEHRDAD HASHEMI, and HOSSEIN DEHGHANI, “ANALYSIS OF THE ANTI PROLIFERATIVE EFFECTS OF CURCUMIN AND NANOCURCUMIN IN MDA-MB231 AS A BREAST CANCER CELL LINE,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 15, no. 1, pp. 231–239, 2016, [Online]. Available: https://sid.ir/paper/288527/en

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