Study of Sedative-Hypnotic Effects of Aloe vera L. Aqueous Extract through Behavioral Evaluations and EEG Recording in Rats

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Abdollahnejad Fatemeh; MOSADDEGH MAHMOOD; Nasoohi Sanaz; MIRNAJAFI ZADEH JAVAD; KAMALINEJAD MOHAMAD; FAIZI MEHRDAD

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Journal: Iranian Journal of Pharmaceutical Research Year:2016 | Volume:15 | Issue:1 Page(s): 293-300

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Title

Study of Sedative-Hypnotic Effects of Aloe vera L. Aqueous Extract through Behavioral Evaluations and EEG Recording in Rats

Author(s)

Keywords

Aloe vera

Insomnia

Sedative-Hypnotic effects

Electroencephalography

Electromyography.

Abstract

In this study, we investigated the sedative and hypnotic effects of the aqueous extract of Aloe vera on rats. In order to evaluate the overall hypnotic effects of the Aloe vera extract, open field and loss of righting reflex tests were primarily used. The sedative and hypnotic effects of the extract were then confirmed by detection of remarkable raise in the total sleeping time through analysis of electroencephalographic (EEG) recordings of animals. Analysis of the EEG recordings showed that there is concomitant change in Rapid Eye Movement (REM) and None Rapid Eye Movement (NREM) sleep in parallel with the prolonged total sleeping time. Results of the current research show that the extract has Sedative-Hypnotic effects on both functional and electrical activities of the brain.

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APA: Copy

Abdollahnejad, Fatemeh, MOSADDEGH, MAHMOOD, Nasoohi, Sanaz, MIRNAJAFI ZADEH, JAVAD, KAMALINEJAD, MOHAMAD, & FAIZI, MEHRDAD. (2016). Study of Sedative-Hypnotic Effects of Aloe vera L. Aqueous Extract through Behavioral Evaluations and EEG Recording in Rats. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 15(1), 293-300. SID. https://sid.ir/paper/288541/en

Vancouver: Copy

Abdollahnejad Fatemeh, MOSADDEGH MAHMOOD, Nasoohi Sanaz, MIRNAJAFI ZADEH JAVAD, KAMALINEJAD MOHAMAD, FAIZI MEHRDAD. Study of Sedative-Hypnotic Effects of Aloe vera L. Aqueous Extract through Behavioral Evaluations and EEG Recording in Rats. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2016;15(1):293-300. Available from: https://sid.ir/paper/288541/en

IEEE: Copy

Fatemeh Abdollahnejad, MAHMOOD MOSADDEGH, Sanaz Nasoohi, JAVAD MIRNAJAFI ZADEH, MOHAMAD KAMALINEJAD, and MEHRDAD FAIZI, “Study of Sedative-Hypnotic Effects of Aloe vera L. Aqueous Extract through Behavioral Evaluations and EEG Recording in Rats,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 15, no. 1, pp. 293–300, 2016, [Online]. Available: https://sid.ir/paper/288541/en

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