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Information Journal Paper

Title

Synthesis, Radiolabeling, and Biological Evaluation of Peptide LIKKPF Functionalized with HYNIC as Apoptosis Imaging Agent

Pages

  415-424

Abstract

 A noninvasive method of detecting exposure of Phosphatidylserine (PS) on the external surface of the plasma membrane such as nuclear imaging could assist the diagnosis and therapy of Apoptosis related pathologies. The most studied imaging agent for Apoptosis is Annexin V so far. Because of limitations of Annexin V other agents have been introduced such as small peptides and molecules. Radiopeptides that have affinity and bind to PS are good candidates for noninvasive imaging of Apoptosis. The LIKKPF, introduced by Burtea et al, with nanomolar affinity for PS, was used as templete. The biological properties of LIKKPF radiolabeled with Tc-99 m was assessed in-vitro using apoptotic Jurkat cells and in-vivo using mouse model of liver Apoptosis. The radiolabeled LIKKPF with 99mTc was stable in human serum at 37˚ C for at least 2 h. Results showed that the radiolabeled LIKKPF has less affinity to PS compare to original phage peptide, but high enough for specific binding to apoptotic cells in-vitro and in-vivo. It is concluded that the less affinity of radiolabeled LIKKPF might be attributed to hydrophobicity of peptide. The future peptides should be more hydrophobic compare to LIKKPF.

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    APA: Copy

    KHOSHBAKHT, SEPIDEH, BEIKI, DAVOOD, GERAMIFAR, PARHAM, KOBARFARD, FARZAD, SABZEVARI, OMID, AMINI, MOHSEN, MEHRNEJAD, FARAMARZ, & SHAHHOSSEINI, SORAYA. (2016). Synthesis, Radiolabeling, and Biological Evaluation of Peptide LIKKPF Functionalized with HYNIC as Apoptosis Imaging Agent. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 15(2), 415-424. SID. https://sid.ir/paper/288612/en

    Vancouver: Copy

    KHOSHBAKHT SEPIDEH, BEIKI DAVOOD, GERAMIFAR PARHAM, KOBARFARD FARZAD, SABZEVARI OMID, AMINI MOHSEN, MEHRNEJAD FARAMARZ, SHAHHOSSEINI SORAYA. Synthesis, Radiolabeling, and Biological Evaluation of Peptide LIKKPF Functionalized with HYNIC as Apoptosis Imaging Agent. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2016;15(2):415-424. Available from: https://sid.ir/paper/288612/en

    IEEE: Copy

    SEPIDEH KHOSHBAKHT, DAVOOD BEIKI, PARHAM GERAMIFAR, FARZAD KOBARFARD, OMID SABZEVARI, MOHSEN AMINI, FARAMARZ MEHRNEJAD, and SORAYA SHAHHOSSEINI, “Synthesis, Radiolabeling, and Biological Evaluation of Peptide LIKKPF Functionalized with HYNIC as Apoptosis Imaging Agent,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 15, no. 2, pp. 415–424, 2016, [Online]. Available: https://sid.ir/paper/288612/en

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