Matrine inhibits diethylnitrosamine-induced HCC proliferation in rats through inducing apoptosis via p53, Bax-dependent caspase-3 activation pathway and down-regulating MLCK overexpression

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ZHANG XIAOLING; Yu Hao

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2016 | Volume:15 | Issue:2 Page(s): 491-499

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Information Journal Paper

Title

Matrine inhibits diethylnitrosamine-induced HCC proliferation in rats through inducing apoptosis via p53, Bax-dependent caspase-3 activation pathway and down-regulating MLCK overexpression

Author(s)

ZHANG XIAOLING | Yu Hao | Issue Writer Certificate

Keywords

Matrine

HCC cell proliferation

Aapoptosis

P53

Myosin light chain kinase

Abstract

The proliferation of hepatocellular carcinoma (HCC) cells is one of the leading causes of liver cancer mortality in humans. The inhibiting effects of Matrine on HCC cell proliferation have been studied, but the mechanism of that inhibition has not been fully elucidated. Since, apoptosis plays an important role in HCC cell proliferation. We examined the apoptosisinducing effect of Matrine on tumor cells. Western blot analysis of P53, Bax, cleaved caspase-3 and Myosin light chain kinase (MLCK) revealed that Matrine induced tumor cell apoptosis by controlling anoikis. It activated P53, Bax-dependent caspase-3 and blocked the ECM-integrin mediated cell survival pathway through down-regulating MLCK over-expression in the liver of rats with diethylnitrosamine (DENA)-induced HCC. Our results suggest that Matrine can inhibit the proliferation of HCC cells through inducing tumor cell apoptosis via activation of the P53 pathway and inhibition of MLCK overexpression. Matrine may thus be used as a potentially promising reagent to inhibit HCC cell proliferation and MLCK may be a novel target for the treatment of HCC.

Cites

The p53 Modulated Cytotoxicity of Ophiocoma scolopendrina Polysaccharide Against Resistance Ovarian Cancer Cells

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APA: Copy

ZHANG, XIAOLING, & Yu, Hao. (2016). Matrine inhibits diethylnitrosamine-induced HCC proliferation in rats through inducing apoptosis via p53, Bax-dependent caspase-3 activation pathway and down-regulating MLCK overexpression. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 15(2), 491-499. SID. https://sid.ir/paper/288636/en

Vancouver: Copy

ZHANG XIAOLING, Yu Hao. Matrine inhibits diethylnitrosamine-induced HCC proliferation in rats through inducing apoptosis via p53, Bax-dependent caspase-3 activation pathway and down-regulating MLCK overexpression. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2016;15(2):491-499. Available from: https://sid.ir/paper/288636/en

IEEE: Copy

XIAOLING ZHANG, and Hao Yu, “Matrine inhibits diethylnitrosamine-induced HCC proliferation in rats through inducing apoptosis via p53, Bax-dependent caspase-3 activation pathway and down-regulating MLCK overexpression,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 15, no. 2, pp. 491–499, 2016, [Online]. Available: https://sid.ir/paper/288636/en

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