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Title

Teratogenic Effect of Verbascoside, Main Constituent of Lippia citriodora Leaves, in Mice

Pages

  521-525

Abstract

 Verbascoside (acteoside), a phenyl propanoid glycoside, comprises 0. 5 to 3. 5 % dry weight of Lippia citriodora leaves. A wide range of biological activities are attributed to Verbascoside including anti-inflammatory, antioxidant, anti-bacterial, anti-tumor, anti-fungal, photoprotective as well as chelating effects. The objective of this study is to evaluate the effect of Verbascoside on pregnancy outcome in mice. Timed-pregnant mice received doses of 1g/kg/day Verbascoside or the vehicle control during organogenesis, intraperitoneally. Maternal body weights were measured throughout pregnancy. The litters were examined for external malformations and skeletal abnormalities. Then they were stained with Alizarin red S and Alcian blue. Maternal exposure to Verbascoside throughout pregnancy did not influence the mean of maternal weight gain. Statistically significant difference was not found in mean number of implantation sites, live and resorbed fetuses between control and experiment groups. Our data demonstrate that the main component of L. citriodora, Verbascoside using during organogenesis possesses no risk to fetuses. However, more research projects are needed to confirm these findings and determine the exact effects of Verbascoside on human embryo development.

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    APA: Copy

    ETEMAD, LEILA, ZAFARI, REZA, MOALLEM, SEYED ADEL, VAHDATI MASHHADIAN, NASER, OSKOUEI SHIRVAN, ZAHRA, & HOSSEINZADEH, HOSSEIN. (2016). Teratogenic Effect of Verbascoside, Main Constituent of Lippia citriodora Leaves, in Mice. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 15(2), 521-525. SID. https://sid.ir/paper/288639/en

    Vancouver: Copy

    ETEMAD LEILA, ZAFARI REZA, MOALLEM SEYED ADEL, VAHDATI MASHHADIAN NASER, OSKOUEI SHIRVAN ZAHRA, HOSSEINZADEH HOSSEIN. Teratogenic Effect of Verbascoside, Main Constituent of Lippia citriodora Leaves, in Mice. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2016;15(2):521-525. Available from: https://sid.ir/paper/288639/en

    IEEE: Copy

    LEILA ETEMAD, REZA ZAFARI, SEYED ADEL MOALLEM, NASER VAHDATI MASHHADIAN, ZAHRA OSKOUEI SHIRVAN, and HOSSEIN HOSSEINZADEH, “Teratogenic Effect of Verbascoside, Main Constituent of Lippia citriodora Leaves, in Mice,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 15, no. 2, pp. 521–525, 2016, [Online]. Available: https://sid.ir/paper/288639/en

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