TWO LUNG CANCER DEVELOPMENT- RELATED GENES, FORKHEAD BOX M1 (FOXM1) AND APOLIPOPROTEIN E (APOE), ARE OVEREXPRESSED IN BRONCHIAL OF PATIENTS AFTER LONG- TERM EXPOSURE TO SULFUR MU

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TAHMASBPOUR EISA; GHANEI MOSTAFA; PANAHI YUNES

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Journal: Iranian Journal of Pharmaceutical Research Year:2017 | Volume:16 | Issue:4 Page(s): 1487-1494

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Title

TWO LUNG CANCER DEVELOPMENT- RELATED GENES, FORKHEAD BOX M1 (FOXM1) AND APOLIPOPROTEIN E (APOE), ARE OVEREXPRESSED IN BRONCHIAL OF PATIENTS AFTER LONG- TERM EXPOSURE TO SULFUR MU

Author(s)

TAHMASBPOUR EISA | GHANEI MOSTAFA | PANAHI YUNES | Issue Writer Certificate

Keywords

APOLIPOPROTEIN E

CANCER

FORKHEAD BOX M1

LUNG

OXIDATIVE STRESS

SULFUR MUSTARD

Abstract

Sulfur mustard (SM) is a strong alkylating and mutagenic compound that targets human airway system. We considered the expression of FORKHEAD BOX M1 (FOXM1) and APOLIPOPROTEIN E (APOE) genes, which are responsible for cell proliferation, differentiation, tumorigenesis, and increased risk of LUNG CANCER, in the LUNG bronchial tissue of patients exposed to SM. After performing pulmonary functional tests (PFTs), 11 human subjects (five controls and six SM-exposed patients) were entered in this study. Total RNA were extracted from all biopsy samples and then cDNA was synthesised for each specimen using RT-PCR. Changes in gene expression were measured using a RT2 Profiler TMPCR Array. PFTs have demonstrated more obstructive and restrictive spirometric patterns among patients compared to the controls. A higher expression was recorded for both examined genes in bronchial of SM-exposed patients. Expression of FOXM1 and APOE genes in bronchial of the patients was significantly (p<0.001) overexpressed by 14.8316 and 3.9504-folds, respectively. Mustard LUNGs were associated with increased expression of FOXM1 and APOE genes, which suggests an increased risk of LUNG CANCER among these patients. Since FOXM1 and APOE are considered as OXIDATIVE STRESS responsive genes, we speculate that increased expression of these genes is more likely linked to overproduction of reactive oxygen species (ROS) and OXIDATIVE STRESS (OS) in mustard LUNGs. Further studies are required at protein level among SM- exposed patients with LUNG CANCER to use these genes as LUNG CANCER biomarkers among these patients.

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APA: Copy

TAHMASBPOUR, EISA, GHANEI, MOSTAFA, & PANAHI, YUNES. (2017). TWO LUNG CANCER DEVELOPMENT- RELATED GENES, FORKHEAD BOX M1 (FOXM1) AND APOLIPOPROTEIN E (APOE), ARE OVEREXPRESSED IN BRONCHIAL OF PATIENTS AFTER LONG- TERM EXPOSURE TO SULFUR MU. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(4), 1487-1494. SID. https://sid.ir/paper/288716/en

Vancouver: Copy

TAHMASBPOUR EISA, GHANEI MOSTAFA, PANAHI YUNES. TWO LUNG CANCER DEVELOPMENT- RELATED GENES, FORKHEAD BOX M1 (FOXM1) AND APOLIPOPROTEIN E (APOE), ARE OVEREXPRESSED IN BRONCHIAL OF PATIENTS AFTER LONG- TERM EXPOSURE TO SULFUR MU. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(4):1487-1494. Available from: https://sid.ir/paper/288716/en

IEEE: Copy

EISA TAHMASBPOUR, MOSTAFA GHANEI, and YUNES PANAHI, “TWO LUNG CANCER DEVELOPMENT- RELATED GENES, FORKHEAD BOX M1 (FOXM1) AND APOLIPOPROTEIN E (APOE), ARE OVEREXPRESSED IN BRONCHIAL OF PATIENTS AFTER LONG- TERM EXPOSURE TO SULFUR MU,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 4, pp. 1487–1494, 2017, [Online]. Available: https://sid.ir/paper/288716/en

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