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Information Journal Paper

Title

OPTIMIZATION OF CULTURE CONDITIONS FOR ENRICHMENT OF SACCHAROMYCES CEREVISIAE WITH DL-α-TOCOPHEROL BY RESPONSE SURFACE METHODOLOGY

Pages

  1546-1554

Abstract

 Designing enriched probiotic supplements may have some advantages including protection of probiotic microorganism from oxidative destruction, improving enzyme activity of the gastrointestinal tract, and probably increasing half- life of micronutrient. In this study SACCHAROMYCES CEREVISIAE enriched with dl-a-tocopherol was produced as an accumulator and transporter of a lipid soluble vitamin for the first time. By using one variable at the time screening studies, three independent variables were selected. OPTIMIZATION of the level of dl- a-tocopherol entrapment in S. cerevisiae cells was performed by using BOX- BEHNKEN design via design expert software. A modified quadratic polynomial model appropriately fit the data. The convex shape of three-dimensional plots reveal that we could calculate the optimal point of the response in the range of parameters. The optimum points of independent parameters to maximize the response were dl-a-tocopherol initial concentration of 7625.82 mg/mL, sucrose concentration of 6.86 % w/v, and shaking speed of 137.70 rpm. Under these conditions, the maximum level of dl-a-tocopherol in dry cell weight of S. cerevisiae was 5.74 mg/g. The resemblance between the R-squared and adjusted R-squared and acceptable value of C.V% revealed acceptability and accuracy of the model.

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    APA: Copy

    MOHAJERI AMIRI, MORTEZA, FAZELI, MOHAMMAD REZA, AMINI, MOHSEN, HAYATI ROODBARI, NASIM, & SAMADI, NASRIN. (2017). OPTIMIZATION OF CULTURE CONDITIONS FOR ENRICHMENT OF SACCHAROMYCES CEREVISIAE WITH DL-α-TOCOPHEROL BY RESPONSE SURFACE METHODOLOGY. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(4), 1546-1554. SID. https://sid.ir/paper/288725/en

    Vancouver: Copy

    MOHAJERI AMIRI MORTEZA, FAZELI MOHAMMAD REZA, AMINI MOHSEN, HAYATI ROODBARI NASIM, SAMADI NASRIN. OPTIMIZATION OF CULTURE CONDITIONS FOR ENRICHMENT OF SACCHAROMYCES CEREVISIAE WITH DL-α-TOCOPHEROL BY RESPONSE SURFACE METHODOLOGY. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(4):1546-1554. Available from: https://sid.ir/paper/288725/en

    IEEE: Copy

    MORTEZA MOHAJERI AMIRI, MOHAMMAD REZA FAZELI, MOHSEN AMINI, NASIM HAYATI ROODBARI, and NASRIN SAMADI, “OPTIMIZATION OF CULTURE CONDITIONS FOR ENRICHMENT OF SACCHAROMYCES CEREVISIAE WITH DL-α-TOCOPHEROL BY RESPONSE SURFACE METHODOLOGY,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 4, pp. 1546–1554, 2017, [Online]. Available: https://sid.ir/paper/288725/en

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