SINAPIC ACID DERIVATIVES AS POTENTIAL ANTI- INFLAMMATORY AGENTS: SYNTHESIS AND BIOLOGICAL EVALUATION

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ZHANG QIONGYU; HU JUN XIAO; KUI XU; LIU CHAO; ZHOU HUI; JIANG XIAOXIN; ZENG LEPING

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Journal Paper

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Journal: Iranian Journal of Pharmaceutical Research Year:2017 | Volume:16 | Issue:4 Page(s): 1405-1414

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Title

SINAPIC ACID DERIVATIVES AS POTENTIAL ANTI- INFLAMMATORY AGENTS: SYNTHESIS AND BIOLOGICAL EVALUATION

Author(s)

Keywords

SINAPIC ACID

INFLAMMATION

NUCLEAR FACTOR- KAPPA B

INTERLEUKIN

Abstract

Transcription factor NF-kB and relevant cytokines IL-6 and IL-8 play a pivotal role in the pathogenesis of INFLAMMATION. SINAPIC ACID is a natural product and was demonstrated to possess anti-inflammatory activity. In this paper, we synthesized a series of SINAPIC ACID derivatives and evaluated their anti-inflammatory effects. The result suggested that all of the targets compounds 7a-j inhibit NF-kB activation and decrease IL-6 and IL-8 expression in BEAS- 2B cells. By our biological assays, we found that all of the prepared compounds displayed stronger anti- inflammatory activities than their precursor SINAPIC ACID. Especially, compounds 7g and 7i, with electron- drawing groups (nitro and fluoro moieties) in the benz imidazole ring, exhibited remarkable anti- INFLAMMATION activity, which was even stronger than the reference drug dexamethasone.

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APA: Copy

ZHANG, QIONGYU, HU, JUN XIAO, KUI, XU, LIU, CHAO, ZHOU, HUI, JIANG, XIAOXIN, & ZENG, LEPING. (2017). SINAPIC ACID DERIVATIVES AS POTENTIAL ANTI- INFLAMMATORY AGENTS: SYNTHESIS AND BIOLOGICAL EVALUATION. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(4), 1405-1414. SID. https://sid.ir/paper/288729/en

Vancouver: Copy

ZHANG QIONGYU, HU JUN XIAO, KUI XU, LIU CHAO, ZHOU HUI, JIANG XIAOXIN, ZENG LEPING. SINAPIC ACID DERIVATIVES AS POTENTIAL ANTI- INFLAMMATORY AGENTS: SYNTHESIS AND BIOLOGICAL EVALUATION. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(4):1405-1414. Available from: https://sid.ir/paper/288729/en

IEEE: Copy

QIONGYU ZHANG, JUN XIAO HU, XU KUI, CHAO LIU, HUI ZHOU, XIAOXIN JIANG, and LEPING ZENG, “SINAPIC ACID DERIVATIVES AS POTENTIAL ANTI- INFLAMMATORY AGENTS: SYNTHESIS AND BIOLOGICAL EVALUATION,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 4, pp. 1405–1414, 2017, [Online]. Available: https://sid.ir/paper/288729/en

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