IN-VITRO STUDY OF KETOPROFEN RELEASE FROM SYNTHESIZED SILICA AEROGELS (AS DRUG CARRIERS) AND EVALUATION OF MATHEMATICAL KINETIC RELEASE MODELS

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MOHAMMADIAN MANIJEH; JAFARZADEH KASHI TAHEREH S.; ERFAN MOHAMMAD; PASHAEI SOORBAGHI FATEMEH

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Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2018 | Volume:17 | Issue:3 Page(s): 818-829

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Title

IN-VITRO STUDY OF KETOPROFEN RELEASE FROM SYNTHESIZED SILICA AEROGELS (AS DRUG CARRIERS) AND EVALUATION OF MATHEMATICAL KINETIC RELEASE MODELS

Author(s)

MOHAMMADIAN MANIJEH | JAFARZADEH KASHI TAHEREH S. | ERFAN MOHAMMAD | PASHAEI SOORBAGHI FATEMEH | Issue Writer Certificate

Keywords

RELEASE KINETIC MODEL

DRUG DELIVERY

SILICA AEROGEL

KETOPROFEN

DRUG DISSOLUTION

Abstract

Silica aerogels are porous and extremely lightweight nano-materials that show interesting properties. These materials, because of biocompatibility, non-harmful to the body, and special physical characteristics such as large surface area and low density have great potential for use in a DRUG DELIVERY system (DDS). The focus of this study is the evaluation of the effects of SILICA AEROGELs on improving the release rate of KETOPROFEN as a relevant model drug of poorly soluble drugs in water. The in-vitro release rate of a conventional crystalline form of pure drug and three samples of drug loaded SILICA AEROGELs with different densities, 0.033, 0.080, and 0.24 g/ cm3 were measured and investigated. The results show that all three samples of SILICA AEROGELs considerably increased (p<0.05) the rate of drug release compared to its crystalline form. The SILICA AEROGEL sample with the lowest density (0.033 gr/cm3) has demonstrated the highest release rate of the drug (approximately five times faster than pure drug). Thus, SILICA AEROGELs could be acceptable carriers for poorly soluble drugs that require treatment with the fast release. Moreover, three RELEASE KINETIC MODELs were fitted with in-vitro drug release data and evaluated. The results indicate that the First-Order model is the best fit with the in-vitro KETOPROFEN release data. Finally, in this article, a new kinetic release equation was obtained based on the first order model and release data, with applying the density of SILICA AEROGEL as an effective index parameter. This equation was proposed to describe KETOPROFEN release rate in SILICA AEROGELs.

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APA: Copy

MOHAMMADIAN, MANIJEH, JAFARZADEH KASHI, TAHEREH S., ERFAN, MOHAMMAD, & PASHAEI SOORBAGHI, FATEMEH. (2018). IN-VITRO STUDY OF KETOPROFEN RELEASE FROM SYNTHESIZED SILICA AEROGELS (AS DRUG CARRIERS) AND EVALUATION OF MATHEMATICAL KINETIC RELEASE MODELS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 17(3), 818-829. SID. https://sid.ir/paper/288762/en

Vancouver: Copy

MOHAMMADIAN MANIJEH, JAFARZADEH KASHI TAHEREH S., ERFAN MOHAMMAD, PASHAEI SOORBAGHI FATEMEH. IN-VITRO STUDY OF KETOPROFEN RELEASE FROM SYNTHESIZED SILICA AEROGELS (AS DRUG CARRIERS) AND EVALUATION OF MATHEMATICAL KINETIC RELEASE MODELS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2018;17(3):818-829. Available from: https://sid.ir/paper/288762/en

IEEE: Copy

MANIJEH MOHAMMADIAN, TAHEREH S. JAFARZADEH KASHI, MOHAMMAD ERFAN, and FATEMEH PASHAEI SOORBAGHI, “IN-VITRO STUDY OF KETOPROFEN RELEASE FROM SYNTHESIZED SILICA AEROGELS (AS DRUG CARRIERS) AND EVALUATION OF MATHEMATICAL KINETIC RELEASE MODELS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 17, no. 3, pp. 818–829, 2018, [Online]. Available: https://sid.ir/paper/288762/en

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