ETHYL ACETATE EXTRACT OF LICORICE ROOT (GLYCYRRHIZA GLABRA) ENHANCES PROLIFERATION AND OSTEOGENIC DIFFERENTIATION OF HUMAN BONE MARROW MESENCHYMAL STEM CELLS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

AZIZSOLTANI AREZOU; PIRI KHOSRO; BEHZAD SAHAR; SOLEIMANI MASOUD; Nekouei Mina; MAHMOUDI ZAHRA; KAZEMI ASAD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Pharmaceutical Research Year:2018 | Volume:17 | Issue:3 Page(s): 1057-1067

Download Full-Text

View:

281

Download:

259

Cites:

Information Journal Paper

Title

ETHYL ACETATE EXTRACT OF LICORICE ROOT (GLYCYRRHIZA GLABRA) ENHANCES PROLIFERATION AND OSTEOGENIC DIFFERENTIATION OF HUMAN BONE MARROW MESENCHYMAL STEM CELLS

Author(s)

Keywords

GLYCYRRHIZA GLABRA

FABACEAE

PHYTOESTROGEN

OSTEOPOROSIS

MESENCHYMAL STEM CELL

DIFFERENTIATION

Abstract

GLYCYRRHIZA GLABRA (G. glabra)has been used as a flavoring and sweetener agent, in addition to its therapeutic properties. It is rich in PHYTOESTROGEN and may prevent OSTEOPOROSIS caused by estrogen deficiency; however, there is no evidence for its effects on proliferation and osteogenesis in MESENCHYMAL STEM CELLs. So, we were encouraged to investigate whether the ethyl acetate extract of licorice root as a source of PHYTOESTROGEN can act similar to estrogen in cell culture. Furthermore, the analysis of the licorice extract (LE) based on HPLC-DAD-ESI-MS indicated that LE comprises PHYTOESTROGEN compounds, such as glabridin and glabrene. In this study, the effects of LE on proliferation of human bone-marrow MESENCHYMAL STEM CELLs (hBM-MSCs) were investigated using MTT assay. In addition, its effects on the osteogenesis were evaluated using alkaline phosphatase activity (ALP), calcium deposition, and bone specific gene expression such as ALP, osteocalcin, Runx2, and BMP-2. The quantitative gene expression was studied by real-time RT-PCR. Our results showed a significant increase in proliferation in presence of LE in concentration 10-50 mg/mL. The DIFFERENTIATION of hBM-MSCs increased in doses of LE (10-25 mg/mL) compared to the control group. The effects of LE were similar to those of 17b-estradiol (E2) (10-8 M) and were abolished by ICI 182, 780 an antagonist of estrogen receptor (ER) (10-7), indicating that the stimulatory effects of LE occur through estrogen receptor-mediated mechanism. Taking these into account, LE may be a potential candidate for prevention of OSTEOPOROSIS in menopausal women.

Cites

No record.

References

No record.

Cite

APA: Copy

AZIZSOLTANI, AREZOU, PIRI, KHOSRO, BEHZAD, SAHAR, SOLEIMANI, MASOUD, Nekouei, Mina, MAHMOUDI, ZAHRA, & KAZEMI, ASAD. (2018). ETHYL ACETATE EXTRACT OF LICORICE ROOT (GLYCYRRHIZA GLABRA) ENHANCES PROLIFERATION AND OSTEOGENIC DIFFERENTIATION OF HUMAN BONE MARROW MESENCHYMAL STEM CELLS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 17(3), 1057-1067. SID. https://sid.ir/paper/288765/en

Vancouver: Copy

AZIZSOLTANI AREZOU, PIRI KHOSRO, BEHZAD SAHAR, SOLEIMANI MASOUD, Nekouei Mina, MAHMOUDI ZAHRA, KAZEMI ASAD. ETHYL ACETATE EXTRACT OF LICORICE ROOT (GLYCYRRHIZA GLABRA) ENHANCES PROLIFERATION AND OSTEOGENIC DIFFERENTIATION OF HUMAN BONE MARROW MESENCHYMAL STEM CELLS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2018;17(3):1057-1067. Available from: https://sid.ir/paper/288765/en

IEEE: Copy

AREZOU AZIZSOLTANI, KHOSRO PIRI, SAHAR BEHZAD, MASOUD SOLEIMANI, Mina Nekouei, ZAHRA MAHMOUDI, and ASAD KAZEMI, “ETHYL ACETATE EXTRACT OF LICORICE ROOT (GLYCYRRHIZA GLABRA) ENHANCES PROLIFERATION AND OSTEOGENIC DIFFERENTIATION OF HUMAN BONE MARROW MESENCHYMAL STEM CELLS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 17, no. 3, pp. 1057–1067, 2018, [Online]. Available: https://sid.ir/paper/288765/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops