THE IMPACT OF CLOPIDOGREL RESISTANCE ON CLINICAL OUTCOME OF IRANIAN PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION

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HAJI AGHAJANI MOHAMMAD; KOBARFARD FARZAD; SHOJAEI SEYED POUZHIA; AHMADPOUR FROOZAN; SAFI OLIA; KAZEMINA NEDA; ZAREPISHE NAEIME; SISTANIZAD MOHAMMAD

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Journal: Iranian Journal of Pharmaceutical Research Year:2018 | Volume:17 | Issue:3 Page(s): 1099-1104

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Title

THE IMPACT OF CLOPIDOGREL RESISTANCE ON CLINICAL OUTCOME OF IRANIAN PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION

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Keywords

PERCUTANEOUS CORONARY INTERVENTION

DRUG RESISTANCE

PLATELET AGGREGATION

MACE

LIGHT TRANSMISSION AGGREGOMETER

Abstract

The aim of current study was evaluating the frequency of clopidogrel resistance and its impact on clinical outcome of patients in Iranian patients. Patients undergoing PERCUTANEOUS CORONARY INTERVENTION in Imam Hussein Medical center, Tehran, Iran, who received standarddosage of clopidogrel (PlavixÒ, Sanofi, France, 600 mg loading dose and 75 mg/day afterward) were recruited. PLATELET AGGREGATION was measured using LIGHT TRANSMISSION AGGREGOMETER. The patients were categorized as responder (platelet aggregation less than 43%) and non-responder (platelet aggregation more than 43%). All patients were evaluated for major adverse cardio vascular events one month and 3 years after the angioplasty based on MACE criteria by phone contact. One hundred and five patients with average age of 60.30 ± 12.2 years entered the study of whom 26 (24.76%) did not respond to clopidogrel. None of patients experienced cardiac events one month after PCI. Three years after PCI, data were collected from 55 (69.62%) and 10 (38.46%) subjects in responder and non-responder groups, respectively. MACE criteria was positive in 4 patients, 3 (5.45%) in responder and 1 (10%) in non-responder group (p=0.28). We did not find any significant differences between clopidogrel resistance and past medical history. In drug history 1 (1.26%) and 4 (15.38%) patients received omeprazole with clopidogrel in responder and none-responder group, respectively (p=0.003). This study showed 24.76% resistance to clopidogrel in Iranian population but, we did not find any correlation between clopidogrel resistance and cardiac events in follow up maybe due to study limitations particularly missed follow-up in non-responder patients.

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APA: Copy

HAJI AGHAJANI, MOHAMMAD, KOBARFARD, FARZAD, SHOJAEI, SEYED POUZHIA, AHMADPOUR, FROOZAN, SAFI, OLIA, KAZEMINA, NEDA, ZAREPISHE, NAEIME, & SISTANIZAD, MOHAMMAD. (2018). THE IMPACT OF CLOPIDOGREL RESISTANCE ON CLINICAL OUTCOME OF IRANIAN PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 17(3), 1099-1104. SID. https://sid.ir/paper/288768/en

Vancouver: Copy

HAJI AGHAJANI MOHAMMAD, KOBARFARD FARZAD, SHOJAEI SEYED POUZHIA, AHMADPOUR FROOZAN, SAFI OLIA, KAZEMINA NEDA, ZAREPISHE NAEIME, SISTANIZAD MOHAMMAD. THE IMPACT OF CLOPIDOGREL RESISTANCE ON CLINICAL OUTCOME OF IRANIAN PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2018;17(3):1099-1104. Available from: https://sid.ir/paper/288768/en

IEEE: Copy

MOHAMMAD HAJI AGHAJANI, FARZAD KOBARFARD, SEYED POUZHIA SHOJAEI, FROOZAN AHMADPOUR, OLIA SAFI, NEDA KAZEMINA, NAEIME ZAREPISHE, and MOHAMMAD SISTANIZAD, “THE IMPACT OF CLOPIDOGREL RESISTANCE ON CLINICAL OUTCOME OF IRANIAN PATIENTS UNDERGOING PERCUTANEOUS CORONARY INTERVENTION,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 17, no. 3, pp. 1099–1104, 2018, [Online]. Available: https://sid.ir/paper/288768/en

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