مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

CHRONIC EXPOSURE OF HUMAN ENDOTHELIAL PROGENITOR CELLS TO DIABETIC CONDITION ABOLISHED THE REGULATED KINETICS ACTIVITY OF EXOSOMES

Pages

  1068-1080

Abstract

 By virtue of lifestyle change, incidence of DIABETES mellitus type 2 is increasingly being raised with different up-surging pathologies. It was showed that ENDOTHELIAL PROGENITOR CELLS(EPCs) were disqualified in neo-angiogenesis induction. Besides, to an aborted differentiation property, malfunctioned paracrine activities worsen off vascular abnormality. Nano-scaled EXOSOMEs play essential roles in reciprocal cell-cell crosstalk via bioactive molecules. To address the effect of diabetic serum on EXOSOME secretion capacity, EPCs were exposed to diabetic condition for seven days. In addition to in-vitro tubulogenesis, migration and LDL uptake assessment, EXOSOME release capacity, and expression profiles of three genes participating in EXOSOME KINETICS, including CD63, Alix and Rab27a, revealed by Real-time PCR method. Data showed diabetic sera not only abolished the in-vitro tubulogenesis, migration and LDL uptake properties but also decreased EXOSOME release and expression of related genes. This study sheds lights on the adverse effect of diabetic condition on EXOSOME KINETICS in EPCs.

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    APA: Copy

    HASSANPOUR, MEHDI, CHERAGHI, OMID, BRAZVAN, BELAL, HIRADFAR, AMIRATAOLLAH, AGHAMOHAMMADZADEH, NASER, RAHBARGHAZI, REZA, & NOURI, MOHAMMAD. (2018). CHRONIC EXPOSURE OF HUMAN ENDOTHELIAL PROGENITOR CELLS TO DIABETIC CONDITION ABOLISHED THE REGULATED KINETICS ACTIVITY OF EXOSOMES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 17(3), 1068-1080. SID. https://sid.ir/paper/288781/en

    Vancouver: Copy

    HASSANPOUR MEHDI, CHERAGHI OMID, BRAZVAN BELAL, HIRADFAR AMIRATAOLLAH, AGHAMOHAMMADZADEH NASER, RAHBARGHAZI REZA, NOURI MOHAMMAD. CHRONIC EXPOSURE OF HUMAN ENDOTHELIAL PROGENITOR CELLS TO DIABETIC CONDITION ABOLISHED THE REGULATED KINETICS ACTIVITY OF EXOSOMES. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2018;17(3):1068-1080. Available from: https://sid.ir/paper/288781/en

    IEEE: Copy

    MEHDI HASSANPOUR, OMID CHERAGHI, BELAL BRAZVAN, AMIRATAOLLAH HIRADFAR, NASER AGHAMOHAMMADZADEH, REZA RAHBARGHAZI, and MOHAMMAD NOURI, “CHRONIC EXPOSURE OF HUMAN ENDOTHELIAL PROGENITOR CELLS TO DIABETIC CONDITION ABOLISHED THE REGULATED KINETICS ACTIVITY OF EXOSOMES,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 17, no. 3, pp. 1068–1080, 2018, [Online]. Available: https://sid.ir/paper/288781/en

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