RELATIONSHIP BETWEEN SERUM METHADONE CONCENTRATION AND COLD PRESSOR PAIN SENSITIVITY IN PATIENTS UNDERGOING METHADONE MAINTENANCE THERAPY

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ZAHARI ZALINA; LEE CHEE SIONG; IBRAHIM MUSLIH ABDULKARIM; MUSA NURFADHLINA; MOHD YASIN MOHD AZHAR; LEE YEONG YEH; TAN SOO CHOON; MOHAMAD NASIR; ISMAIL RUSLI

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Journal: Iranian Journal of Pharmaceutical Research Year:2018 | Volume:17 | Issue:SUPPLEMENT Page(s): 8-16

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Title

RELATIONSHIP BETWEEN SERUM METHADONE CONCENTRATION AND COLD PRESSOR PAIN SENSITIVITY IN PATIENTS UNDERGOING METHADONE MAINTENANCE THERAPY

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Keywords

COLD PRESSOR PAIN

PAIN THRESHOLD

PAIN TOLERANCE

PAIN INTENSITY

METHADONE

METHADONE MAINTENANCE THERAPY (MMT)

Abstract

Hyperalgesia is a common clinical phenomenon among opioid dependent patients on METHADONE maintenance therapy (MMT) and it may be associated with undertreated pain and/ or therapeutic failure. This study aimed to investigate association between serum METHADONE concentration (SMC) and COLD PRESSOR PAIN responses. COLD PRESSOR PAIN responses in 147 opioid dependent patients on MMT were assessed using cold pressor test (CPT) at 0 h and at 2, 4, 8, 12, and 24 h after the dose intake. Blood samples were collected at 24 h after the dose. Serum METHADONE concentrations were measured using the METHADONE ELISA kit andclassified into two categories: <400 ng/mL and ³ 400 ng/mL. Eighty-eight patients (59.9%) had trough concentrations of <400 ng/mL and 40.1% had trough concentrations of ³ 400 ng/mL. There were significant effects of SMC on the COLD PRESSOR PAIN threshold (p=0.019). Patients with concentrations <400 ng/mL had significantly higher (almost 60% higher) COLD PRESSOR PAIN threshold (adjusted mean (95% CI) =30.15 (24.29, 36.01) s) compared to those with concentrations of ³ 400 ng/mL (18.93 (11.77, 26.08) seconds). There was also a 20% difference in PAIN TOLERANCE, and 6% difference in COLD PRESSOR PAIN intensity score, neither of which were significant statistically (p>0.05). Our results suggest an association of trough METHADONE concentration with the COLD PRESSOR PAIN threshold among opioid dependent patients on MMT. It would be useful to study the mechanisms underlying this association to help managing pain in such a population.

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APA: Copy

ZAHARI, ZALINA, LEE, CHEE SIONG, IBRAHIM, MUSLIH ABDULKARIM, MUSA, NURFADHLINA, MOHD YASIN, MOHD AZHAR, LEE, YEONG YEH, TAN, SOO CHOON, MOHAMAD, NASIR, & ISMAIL, RUSLI. (2018). RELATIONSHIP BETWEEN SERUM METHADONE CONCENTRATION AND COLD PRESSOR PAIN SENSITIVITY IN PATIENTS UNDERGOING METHADONE MAINTENANCE THERAPY. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 17(SUPPLEMENT), 8-16. SID. https://sid.ir/paper/288784/en

Vancouver: Copy

ZAHARI ZALINA, LEE CHEE SIONG, IBRAHIM MUSLIH ABDULKARIM, MUSA NURFADHLINA, MOHD YASIN MOHD AZHAR, LEE YEONG YEH, TAN SOO CHOON, MOHAMAD NASIR, ISMAIL RUSLI. RELATIONSHIP BETWEEN SERUM METHADONE CONCENTRATION AND COLD PRESSOR PAIN SENSITIVITY IN PATIENTS UNDERGOING METHADONE MAINTENANCE THERAPY. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2018;17(SUPPLEMENT):8-16. Available from: https://sid.ir/paper/288784/en

IEEE: Copy

ZALINA ZAHARI, CHEE SIONG LEE, MUSLIH ABDULKARIM IBRAHIM, NURFADHLINA MUSA, MOHD AZHAR MOHD YASIN, YEONG YEH LEE, SOO CHOON TAN, NASIR MOHAMAD, and RUSLI ISMAIL, “RELATIONSHIP BETWEEN SERUM METHADONE CONCENTRATION AND COLD PRESSOR PAIN SENSITIVITY IN PATIENTS UNDERGOING METHADONE MAINTENANCE THERAPY,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 17, no. SUPPLEMENT, pp. 8–16, 2018, [Online]. Available: https://sid.ir/paper/288784/en

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