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Information Journal Paper

Title

STUDY OF THE EFFECT OF MEMANTINE ON NEGATIVE SIGN IN PATIENTS WITH SCHIZOPHRENIA AND SCHIZOAFFECTIVE DISORDERS

Pages

  122-129

Abstract

 Memantine, an uncompetitive antagonist of glutamate receptor of the N-methyl-D-aspartate type is approved for the treatment of moderate to severe Alzheimer disease (1). A growing body of evidence supports a link between the glutamatergic neurotransmission and SCHIZOPHRENIA (2). The aim of this study was to examine the efficacy and safety of MEMANTINE as an adjunctive treatment for antipsychotics in patient with psychopathology of SCHIZOPHRENIA and schizoaffective. In this study, we assessed the effect of MEMANTINE on the pro-inflammatory cytokines such as IL6, TNFa and CRP. In this double-blind, placebo-controlled study, participants were assigned to receive (5-20 mg/day) MEMANTINE (n=29) or placebo (n=29), in addition to continuing treatment with antipsychotic for 12 weeks. The primary efficacy measure was the level of pro-inflammatory cytokines (TNFA, IL6, CRP). Safety was assessed by means of physical examination, clinical laboratory evaluation, recording of adverse event (AEs), and measure of extrapyramidal symptoms. At end point, comparison of BIOMARKERS (IL6, TNFα and CRP) in two groups before and after treatment showed a significant decrease of TNFa (P<0.001), but the difference was not significant in CRP and IL6 level (p=0.92 and p=0.77, respectively). The frequency of serious AEs in the MEMANTINE vs. placebo group was similar.

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    APA: Copy

    TAVAKOLI ARDAKANI, MARIA, ABBASPOUR, HAMIDEH, FARHADI NASAB, ABDULLAH, MAZAHERI MEIBODI, AZADEH, & KHERADMAND, ALI. (2018). STUDY OF THE EFFECT OF MEMANTINE ON NEGATIVE SIGN IN PATIENTS WITH SCHIZOPHRENIA AND SCHIZOAFFECTIVE DISORDERS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 17(SUPPLEMENT), 122-129. SID. https://sid.ir/paper/288800/en

    Vancouver: Copy

    TAVAKOLI ARDAKANI MARIA, ABBASPOUR HAMIDEH, FARHADI NASAB ABDULLAH, MAZAHERI MEIBODI AZADEH, KHERADMAND ALI. STUDY OF THE EFFECT OF MEMANTINE ON NEGATIVE SIGN IN PATIENTS WITH SCHIZOPHRENIA AND SCHIZOAFFECTIVE DISORDERS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2018;17(SUPPLEMENT):122-129. Available from: https://sid.ir/paper/288800/en

    IEEE: Copy

    MARIA TAVAKOLI ARDAKANI, HAMIDEH ABBASPOUR, ABDULLAH FARHADI NASAB, AZADEH MAZAHERI MEIBODI, and ALI KHERADMAND, “STUDY OF THE EFFECT OF MEMANTINE ON NEGATIVE SIGN IN PATIENTS WITH SCHIZOPHRENIA AND SCHIZOAFFECTIVE DISORDERS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 17, no. SUPPLEMENT, pp. 122–129, 2018, [Online]. Available: https://sid.ir/paper/288800/en

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