PREPARATION, OPTIMIZATION AND TOXICITY EVALUATION OF (SPION-PLGA) ±PEG NANOPARTICLES LOADED WITH GEMCITABINE AS A MULTIFUNCTIONAL NANOPARTICLE FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS

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HAMZIAN NIMA; HASHEMI MARYAM; GHORBANI MAHDI; BAHREYNI TOOSI MOHAMMAD HOSSEIN; RAMEZANI MOHAMMAD

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Journal: Iranian Journal of Pharmaceutical Research Year:2017 | Volume:16 | Issue:1 Page(s): 8-21

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Title

PREPARATION, OPTIMIZATION AND TOXICITY EVALUATION OF (SPION-PLGA) ±PEG NANOPARTICLES LOADED WITH GEMCITABINE AS A MULTIFUNCTIONAL NANOPARTICLE FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS

Author(s)

Keywords

GEMCITABINE

MULTIFUNCTIONAL NANOPARTICLES

SPION- PLGA DRAG DELIVERY SYSTEM

OPTIMIZED PREPARATION PARAMETERS

HUMAN BREAST CANCER CELL LINE (MCF-7)

Abstract

The aim of this study was to develop a novel multifunctional nanoparticle, which encapsulates SPION and GEMCITABINE in PLGA±PEG to form multifunctional drug delivery system. For this aim, super paramagnetic iron oxide nanoparticles (SPIONs) were simultaneously synthesized and encapsulated with GEMCITABINE (Gem) in PLGA±PEG copolymers via W/O/W double emulsification method. Optimum size and encapsulation efficiency for radio sensitization, hyperthermia and diagnostic applications were considered and the preparation parameters systematically were investigated and physicochemical characteristics of optimized nanoparticle were studied. Then SPION-PLGA and PLGA- Gem nanoparticles were prepared with the same optimized parameters and the toxicity of these nanoparticles was compared with GEMCITABINE in human breast cancer cell line (MCF-7). The optimum preparation parameters were obtained with Gem/polymer equal to 0.04, SPION/polymer equal to 0.8 and 1% sucrose per 20 mg of polymer. The hydrodynamic diameters of all nanoparticles were under 200 nm. Encapsulation efficiency was adjusted between 13.2% to 16.1% for GEMCITABINE and 48.2% to 50.1% for SPION. In-vitro GEMCITABINE release kinetics had controlled behavior. Enhancement ratios for PLGA- Gem and SPION- PLGA- Gem at concentration of nanoparticles equal to IC50 of GEMCITABINE were 1.53 and 1.89 respectively. The statistical difference was significant (p -value=0.006 for SPION- PLGA- Gem and p -value=0.015 for PLGA- Gem compared with GEMCITABINE). In conclusion, we have successfully developed a GEMCITABINE loaded super paramagnetic PLGA- Iron Oxide multifunctional drag delivery system. Future work includes in-vitro and in-vivo investigation of radio sensitization and other application of these nanoparticles.

Cites

Optimization of Superparamagnetic Iron Oxide Nanoparticles-Trimethyl Chitosan (SPION-TMC) as a siRNA Carrier to Inhibit HIV-1 nef

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APA: Copy

HAMZIAN, NIMA, HASHEMI, MARYAM, GHORBANI, MAHDI, BAHREYNI TOOSI, MOHAMMAD HOSSEIN, & RAMEZANI, MOHAMMAD. (2017). PREPARATION, OPTIMIZATION AND TOXICITY EVALUATION OF (SPION-PLGA) ±PEG NANOPARTICLES LOADED WITH GEMCITABINE AS A MULTIFUNCTIONAL NANOPARTICLE FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(1), 8-21. SID. https://sid.ir/paper/288803/en

Vancouver: Copy

HAMZIAN NIMA, HASHEMI MARYAM, GHORBANI MAHDI, BAHREYNI TOOSI MOHAMMAD HOSSEIN, RAMEZANI MOHAMMAD. PREPARATION, OPTIMIZATION AND TOXICITY EVALUATION OF (SPION-PLGA) ±PEG NANOPARTICLES LOADED WITH GEMCITABINE AS A MULTIFUNCTIONAL NANOPARTICLE FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(1):8-21. Available from: https://sid.ir/paper/288803/en

IEEE: Copy

NIMA HAMZIAN, MARYAM HASHEMI, MAHDI GHORBANI, MOHAMMAD HOSSEIN BAHREYNI TOOSI, and MOHAMMAD RAMEZANI, “PREPARATION, OPTIMIZATION AND TOXICITY EVALUATION OF (SPION-PLGA) ±PEG NANOPARTICLES LOADED WITH GEMCITABINE AS A MULTIFUNCTIONAL NANOPARTICLE FOR THERAPEUTIC AND DIAGNOSTIC APPLICATIONS,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 1, pp. 8–21, 2017, [Online]. Available: https://sid.ir/paper/288803/en

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