DOXORUBICIN LOADED DNA APTAMER LINKED MYRISTILATED CHITOSAN NANOGEL FOR TARGETED DRUG DELIVERY TO PROSTATE CANCER

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Atabi Fereshteh; MOUSAVI GARGARIB SEYED LATIF; HASHEMI MEHRDAD; YAGHMAEI PARICHEHREH

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Journal: Iranian Journal of Pharmaceutical Research Year:2017 | Volume:16 | Issue:1 Page(s): 35-49

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Title

DOXORUBICIN LOADED DNA APTAMER LINKED MYRISTILATED CHITOSAN NANOGEL FOR TARGETED DRUG DELIVERY TO PROSTATE CANCER

Author(s)

Atabi Fereshteh | MOUSAVI GARGARIB SEYED LATIF | HASHEMI MEHRDAD | YAGHMAEI PARICHEHREH | Issue Writer Certificate

Keywords

DOX

MCS

NANOGEL

APTAMER

TARGETED DRUG DELIVERY

PROSTATE CANCER

Abstract

Recently, specific attention has been paid to APTAMERs, short DNA or RNA, as a tool for cancer diagnosis and therapy. In the present study MCS NANOGELs were prepared by Myristate: Chitosan at 1: 9 ratio and were characterized by several techniques. A selected ssDNA APTAMER (Apt) capable of detecting LNCaP cells was linked to Myristilated Chitosan NANOGELs (Apt- MCS) by glutaraldehyde and loaded with DOXorubicin (DOX) to be used in TARGETED DRUG DELIVERY against the PROSTATE CANCER cells. LNCaP and PC-3 cells were treated with Apt-MCS-DOX complex and the binding efficiency was estimated by flow cytometry. The binding affinity of the selected APTAMERs was above 70% compared to the initial library. The loading capacity of the NANOGEL was as high as 97% and up to 40% of DOX were released from MCS within 15 days. Cytotoxicity of nanodrug on LNCaP cells was determined by MTT assay. Apt- MCS-DOX was specifically binded to LNCaP cells whereas it didn’t show any specificity to PC-3 cells as a negative control. Both MCS-DOX and Apt-MCS-DOX showed a lethal effect on LNCaP cells. Our results can lead to an APTAMER based simple and applicable technique for early diagnosis and treatment of cancerous cells.

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APA: Copy

Atabi, Fereshteh, MOUSAVI GARGARIB, SEYED LATIF, HASHEMI, MEHRDAD, & YAGHMAEI, PARICHEHREH. (2017). DOXORUBICIN LOADED DNA APTAMER LINKED MYRISTILATED CHITOSAN NANOGEL FOR TARGETED DRUG DELIVERY TO PROSTATE CANCER. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), 16(1), 35-49. SID. https://sid.ir/paper/288809/en

Vancouver: Copy

Atabi Fereshteh, MOUSAVI GARGARIB SEYED LATIF, HASHEMI MEHRDAD, YAGHMAEI PARICHEHREH. DOXORUBICIN LOADED DNA APTAMER LINKED MYRISTILATED CHITOSAN NANOGEL FOR TARGETED DRUG DELIVERY TO PROSTATE CANCER. IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR)[Internet]. 2017;16(1):35-49. Available from: https://sid.ir/paper/288809/en

IEEE: Copy

Fereshteh Atabi, SEYED LATIF MOUSAVI GARGARIB, MEHRDAD HASHEMI, and PARICHEHREH YAGHMAEI, “DOXORUBICIN LOADED DNA APTAMER LINKED MYRISTILATED CHITOSAN NANOGEL FOR TARGETED DRUG DELIVERY TO PROSTATE CANCER,” IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH (IJPR), vol. 16, no. 1, pp. 35–49, 2017, [Online]. Available: https://sid.ir/paper/288809/en

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